Fig. 1
From: Is immunotherapy in the future of therapeutic management of sarcomas?
CAR-T cells therapy. Patients’ autologous T cells, can be actively extracted through leukapheresis, reprogrammed ex vivo through an inactive or non-viral vector to introduce a gene sequence capable of expressing a particular receptor (CAR-T) on the lymphocyte surface. Depending on the gene sequences introduced, CAR-T cells can express various receptors binding specific antigen tumor related (HER2, GD2, IL11). CAR-T cells are then selected, "expanded" ex vivo, and reinfused into the host