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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinoma

Fig. 5

DKC1 knockdown inhibits LUAD proliferation in vivo. a Images of control and DKC1 knockdown PC-9 xenograft tumors obtained 30 days after subcutaneous inoculation. b Volume of control and DKC1 knockdown PC-9 xenograft tumors recorded at the indicated times. c Weight of control and DKC1 knockdown PC-9 xenograft tumors 30 days after inoculation. d H&E and IHC staining of DKC1, Ki67 and γH2A.X in control and DKC1 knockdown PC-9 xenograft tumor. The left panel shows the representative images and the right panel shows the quantitative analysis of DKC1, Ki67 or γH2A.X-positive cells according to integral optical density (IOD). Scale bar: 50 µm. *P < 0.05, **P < 0.01, ***P < 0.001

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