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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinoma

Fig. 2

DKC1 knockdown inhibits LUAD cell proliferation. a Expression of DKC1 in LUAD cell lines (A549 and PC-9) after lentiviral transduction of shRNA against DKC1 or nonspecific control. b Cell growth curve of LUAD cell lines (A549 and PC-9) after DKC1 knockdown. c Colony formation assays of DKC1 knockdown and control cells. The left panel shows representative colony formation images; the right panel shows a bar graph of the number of colonies per well (mean ± SD). d Cell cycle assays of DKC1 knockdown A549 and PC-9 cells and control cells. e, f The effect of DKC1 inhibitor pyrazofurin on the growth (e) and colony formation (f) of A549 and PC-9 cells. *P < 0.05, **P < 0.01, ***P < 0.001

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