Fig. 7

LDHA inhibition increases DNA injury through ROS production. a A549 cells pretreated with 20 mM oxmate were irradiated at 6 Gy and collected at 0, 2 and 24 h after irradiation, DNA damage detected by the comet assay. b, c Oxamate increased both comet tail length and percentage of DNA in the tail significantly after irradiation, 50 cells in each group were counted and analyzed. d, e LDHA expression was associated with DNA repair capability, as well as G1/S DNA Damage Checkpoints signaling pathway. *p < 0.05, compared to the control group; ^#p < 0.05, compared to the irradiation group