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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench

Fig. 5

Combination of LDHA inhibition and IR induces both apoptosis and autophagy. a–c LDHA inhibition significantly promotes cell apoptosis after treatment with 6 Gy X-ray irradiation for 24 h. d Using MD/PI double staining, autophagy was detected in A549 cells after oxamate treatment, and interacted with apoptosis induced by irradiation. Autophagosomes appear bright green fluorescence and apoptotic nucleus appear red fluorescence. Error bars represent ± SD of N = 3 experiments, *p < 0.05, compared to the control group; #p < 0.05, compared to the irradiation group

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Journal of Translational Medicine

ISSN: 1479-5876

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