Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry

Hu, Cheng; Wang, Tao; Zhuang, Xiaoyu; Sun, Qiaoli; Wang, Xiaochun; Lin, Hui; Feng, Mingli; Zhang, Jiaqi; Cao, Qin; Jiang, Yuanye

doi:10.1186/s12967-021-02820-7

Table 2 Efficiency comparison of diagnostic indicators

From: Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry

No	Name	AUC	95% CI		Sensitivity	Specificity
No	Name	AUC	Lower limit	Upper limit	Sensitivity	Specificity
1	LysoPC(20:3(8Z,11Z,14Z))	0.97	0.933	1	85.19	100.00
2	Succinic acid	0.963	0.917	1	100.00	88.89
3	LysoPC(22:5(7Z,10Z,13Z,16Z,19Z))	0.949	0.896	1	96.30	85.19
4	Indole	0.947	0.881	1	88.89	96.30
5	LysoPC(22:4(7Z,10Z,13Z,16Z))	0.942	0.887	0.998	81.48	92.59
6	Oleic acid	0.938	0.878	0.998	85.19	92.59
7	Desaminotyrosine	0.926	0.849	1	81.48	92.59
8	L-Phenylalanine	0.918	0.838	0.997	92.59	81.48
9	L-Tryptophan	0.915	0.825	1	85.19	96.30
10	LysoPE(22:2(13Z,16Z)/0:0)	0.915	0.837	0.993	85.19	85.19
11	Leukotriene C5	0.909	0.831	0.988	92.59	81.48
12	1-Alkyl-2-acylglycerophosphoethanolamine	0.905	0.829	0.981	81.48	81.48
13	LysoPE(0:0/20:3(5Z,8Z,11Z))	0.905	0.83	0.981	77.78	88.89
14	L-Lysine	0.905	0.815	0.995	85.19	88.89
15	LysoPE(0:0/22:4(7Z,10Z,13Z,16Z))	0.9	0.82	0.979	96.30	70.37
16	Homovanillic acid	0.9	0.801	0.999	88.89	96.30
17	Sulfuric acid	0.894	0.81	0.979	77.78	88.89
18	LysoPE(16:1(9Z)/0:0)	0.893	0.806	0.98	92.59	74.07
19	Coumarone	0.886	0.797	0.975	77.78	88.89
20	LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))	0.885	0.796	0.974	77.78	88.89
21	LysoPC(20:4(8Z,11Z,14Z,17Z))	0.879	0.784	0.975	81.48	85.19
22	LysoPE(0:0/22:5(4Z,7Z,10Z,13Z,16Z))	0.878	0.78	0.976	74.07	92.59
23	Benzoic acid	0.877	0.784	0.969	77.78	88.89
24	LysoPC (20:2(11Z,14Z))	0.87	0.768	0.972	74.07	100.00
25	LysoPE(0:0/24:6(6Z,9Z,12Z,15Z,18Z,21Z))	0.87	0.761	0.978	85.19	81.48
26	LysoPC (20:4(5Z,8Z,11Z,14Z))	0.868	0.771	0.965	81.48	85.19
27	1-arachidonoyl-sn-glycero-3-phosphoethanolamine	0.867	0.774	0.96	88.89	70.37
28	1-Acyl-sn-glycero-3-phosphoethanolamine	0.863	0.745	0.98	74.07	96.30
29	L-methionine	0.86	0.758	0.963	85.19	77.78
30	4-Hydroxycinnamic acid	0.855	0.753	0.956	70.37	92.59
31	Arachidonic acid	0.85	0.75	0.951	85.19	70.37
32	L-TYROSINE	0.846	0.741	0.952	70.37	92.59
33	L-Lactic Acid	0.845	0.738	0.952	92.59	66.67
34	Palmitic Acid	0.844	0.72	0.967	85.19	88.89
35	LysoPE(20:1(11Z)/0:0)	0.841	0.73	0.952	85.19	77.78
36	LysoPC(18:2(9Z,12Z))	0.833	0.724	0.941	70.37	92.59
37	LysoPC(18:1(9Z))	0.826	0.711	0.94	70.37	96.30
38	Ethyl acetate	0.824	0.709	0.94	74.07	88.89
39	1-[(9Z)-hexadecenoyl]-sn-glycero-3-phosphocholine	0.822	0.708	0.935	96.30	59.26
40	LysoPC (15:0)	0.82	0.694	0.947	77.78	92.59
41	Glycerylphosphorylcholine	0.818	0.688	0.947	77.78	92.59
42	LysoPC(18:3(9Z,12Z,15Z))	0.816	0.706	0.926	74.07	77.78
43	Uric Acid	0.815	0.69	0.939	66.67	92.59
44	2-Acyl-sn-glycero-3-phosphoethanolamine	0.811	0.694	0.928	81.48	70.37
45	Stearic acid	0.793	0.664	0.922	70.37	85.19
46	LysoPE (0:0/20:0)	0.785	0.65	0.92	77.78	74.07
47	L-Palmitoylcarnitine	0.761	0.628	0.895	70.37	85.19
48	LysoPE(0:0/16:0)	0.76	0.626	0.894	77.78	66.67
49	2-linoleoyl-sn-glycero-3-phosphoethanolamine	0.749	0.618	0.88	66.67	77.78
50	Platelet-activating factor	0.708	0.563	0.852	51.85	96.30
51	L-Carnitine	0.705	0.568	0.842	59.26	74.07
52	1-heptadecanoyl-sn-glycero-3-phosphocholine	0.672	0.52	0.824	55.56	85.19
53	L-Valine	0.236	0.102	0.37	14.81	33.33
54	L-Pyroglutamic acid	0.091	0.007	0.174	22.22	7.41
55	Citric acid	0.056	0	0.131	3.70	7.41

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