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Table 2 Efficiency comparison of diagnostic indicators

From: Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry

No Name AUC 95% CI Sensitivity Specificity
Lower limit Upper limit
1 LysoPC(20:3(8Z,11Z,14Z)) 0.97 0.933 1 85.19 100.00
2 Succinic acid 0.963 0.917 1 100.00 88.89
3 LysoPC(22:5(7Z,10Z,13Z,16Z,19Z)) 0.949 0.896 1 96.30 85.19
4 Indole 0.947 0.881 1 88.89 96.30
5 LysoPC(22:4(7Z,10Z,13Z,16Z)) 0.942 0.887 0.998 81.48 92.59
6 Oleic acid 0.938 0.878 0.998 85.19 92.59
7 Desaminotyrosine 0.926 0.849 1 81.48 92.59
8 L-Phenylalanine 0.918 0.838 0.997 92.59 81.48
9 L-Tryptophan 0.915 0.825 1 85.19 96.30
10 LysoPE(22:2(13Z,16Z)/0:0) 0.915 0.837 0.993 85.19 85.19
11 Leukotriene C5 0.909 0.831 0.988 92.59 81.48
12 1-Alkyl-2-acylglycerophosphoethanolamine 0.905 0.829 0.981 81.48 81.48
13 LysoPE(0:0/20:3(5Z,8Z,11Z)) 0.905 0.83 0.981 77.78 88.89
14 L-Lysine 0.905 0.815 0.995 85.19 88.89
15 LysoPE(0:0/22:4(7Z,10Z,13Z,16Z)) 0.9 0.82 0.979 96.30 70.37
16 Homovanillic acid 0.9 0.801 0.999 88.89 96.30
17 Sulfuric acid 0.894 0.81 0.979 77.78 88.89
18 LysoPE(16:1(9Z)/0:0) 0.893 0.806 0.98 92.59 74.07
19 Coumarone 0.886 0.797 0.975 77.78 88.89
20 LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)) 0.885 0.796 0.974 77.78 88.89
21 LysoPC(20:4(8Z,11Z,14Z,17Z)) 0.879 0.784 0.975 81.48 85.19
22 LysoPE(0:0/22:5(4Z,7Z,10Z,13Z,16Z)) 0.878 0.78 0.976 74.07 92.59
23 Benzoic acid 0.877 0.784 0.969 77.78 88.89
24 LysoPC (20:2(11Z,14Z)) 0.87 0.768 0.972 74.07 100.00
25 LysoPE(0:0/24:6(6Z,9Z,12Z,15Z,18Z,21Z)) 0.87 0.761 0.978 85.19 81.48
26 LysoPC (20:4(5Z,8Z,11Z,14Z)) 0.868 0.771 0.965 81.48 85.19
27 1-arachidonoyl-sn-glycero-3-phosphoethanolamine 0.867 0.774 0.96 88.89 70.37
28 1-Acyl-sn-glycero-3-phosphoethanolamine 0.863 0.745 0.98 74.07 96.30
29 L-methionine 0.86 0.758 0.963 85.19 77.78
30 4-Hydroxycinnamic acid 0.855 0.753 0.956 70.37 92.59
31 Arachidonic acid 0.85 0.75 0.951 85.19 70.37
32 L-TYROSINE 0.846 0.741 0.952 70.37 92.59
33 L-Lactic Acid 0.845 0.738 0.952 92.59 66.67
34 Palmitic Acid 0.844 0.72 0.967 85.19 88.89
35 LysoPE(20:1(11Z)/0:0) 0.841 0.73 0.952 85.19 77.78
36 LysoPC(18:2(9Z,12Z)) 0.833 0.724 0.941 70.37 92.59
37 LysoPC(18:1(9Z)) 0.826 0.711 0.94 70.37 96.30
38 Ethyl acetate 0.824 0.709 0.94 74.07 88.89
39 1-[(9Z)-hexadecenoyl]-sn-glycero-3-phosphocholine 0.822 0.708 0.935 96.30 59.26
40 LysoPC (15:0) 0.82 0.694 0.947 77.78 92.59
41 Glycerylphosphorylcholine 0.818 0.688 0.947 77.78 92.59
42 LysoPC(18:3(9Z,12Z,15Z)) 0.816 0.706 0.926 74.07 77.78
43 Uric Acid 0.815 0.69 0.939 66.67 92.59
44 2-Acyl-sn-glycero-3-phosphoethanolamine 0.811 0.694 0.928 81.48 70.37
45 Stearic acid 0.793 0.664 0.922 70.37 85.19
46 LysoPE (0:0/20:0) 0.785 0.65 0.92 77.78 74.07
47 L-Palmitoylcarnitine 0.761 0.628 0.895 70.37 85.19
48 LysoPE(0:0/16:0) 0.76 0.626 0.894 77.78 66.67
49 2-linoleoyl-sn-glycero-3-phosphoethanolamine 0.749 0.618 0.88 66.67 77.78
50 Platelet-activating factor 0.708 0.563 0.852 51.85 96.30
51 L-Carnitine 0.705 0.568 0.842 59.26 74.07
52 1-heptadecanoyl-sn-glycero-3-phosphocholine 0.672 0.52 0.824 55.56 85.19
53 L-Valine 0.236 0.102 0.37 14.81 33.33
54 L-Pyroglutamic acid 0.091 0.007 0.174 22.22 7.41
55 Citric acid 0.056 0 0.131 3.70 7.41