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Table 3 Hemodynamic data during HUT in ME/CFS patients with a normal HRBP response (group 1), with POTS (group 2) and with dOH (group 3), all with a significant CBF decrease as measured during HUT

From: Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome)

HUT data Group 1
NormHRBP (n = 105)
Group 2
POTS (n = 39)
Group 3
dOH (n = 27)
Ordinary one-way ANOVA with post hoc Tukey’s test
HR supine (bpm) 73 (11) 77 (14) 73 (10) F (2, 168) = 1.83; p = 0.16
HR end tilt (bpm) 90 (14) 114 (24) 90 (16) F (2, 168) = 29.52; p < 0.0001; 1vs2 p < 0.0001; 1vs3 p = 0.99; 2vs3 p < 0.0001
SBP supine (mmHg) 134 (15) 132 (16) 142 (19) F (2, 168) = 3.14; p = 0.04#
SBP end tilt (mmHg) 131 (16) 119 (24) 109 (16) F (2, 168) = 19.14; p < 0.0001; 1vs2 p = 0.0008; 1vs3 p < 0.0001; 2vs3 p = 0.09
DBP supine (mmHg) 79 (8) 78 (8) 81 (9) F (2, 168) = 1.21; p = 0.30
DBP end tilt (mmHg) 84 (9) 81 (16) 72 (13) F (2, 168) = 10.91; p < 0.0001; 1vs2 p = 0.25; 1vs3 p < 0.0001; 2vs3 p = 0.01#
CBF supine (ml/min) 628 (107) 608 (96) 611 (98) F (2, 168) = 0.70; p = 0.50
CBF end tilt (ml/min) 456 (83) 435 (79) 435 (79) F (2, 168) = 1.29; p = 0.28
%CBF reduction − 27.4 (6.1) − 28.6 (5.3) − 28.8 (4.9) F (2, 168) = 0.98; p = 0.38
  1. CBF cerebral blood flow, DBP diastolic blood pressure, dOH delayed orthostatic hypotension during HUT, HR heart rate, HUT head-up tilt test, NormHRBP normal heart rate and blood pressure response during HUT, POTS postural orthostatic tachycardia syndrome during HUT, SBP systolic blood pressure
  2. #A p-value of < 0.01 was considered significantly different for this study