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Table 1 Demographic and clinical characteristics of the study population and cohorts according to cigarette and alcohol intake status

From: Association between cigarette smoking and colorectal cancer sidedness: A multi-center big-data platform-based analysis

Variable

All cases (N = 46,166)

Cigarette smoking status

Ever (n = 10,712)

Never (n = 35,454)

P value

Age, years

   

.14 a

 18−39

2359 (5.11%)

371 (3.46%)

1988 (5.61%)

 

 40−59

18,028 (39.05%)

4438 (41.43%)

13,590 (38.33%)

 

 60−79

23,297 (50.46%)

5504 (51.38%)

17,793 (50.19%)

 

  ≥ 80

2482 (5.38%)

399 (3.72%)

2083 (5.88%)

 

Sex

   

 < .001

 Male

27,869 (60.37%)

10,202 (95.24%)

17,667 (49.83%)

 

 Female

18,297 (39.63%)

510 (4.76%)

17,787 (50.17%)

 

Year of diagnosis

   

 < .001

 2000−2011

5962 (12.91%)

1131 (10.56%)

4831 (13.63%)

 

 2012−2014

18,822 (40.77%)

4274 (39.90%)

14,548 (41.03%)

 

 2015−2018

21,382 (46.32%)

5307 (49.54%)

16,075 (45.34%)

 

Primary tumor location

   

 < .001

 Cecum, ascending and transverse colon cancer

6393 (13.85%)

1175 (10.97%)

5218 (14.72%)

 

 Splenic flexure, descending and sigmoid colon cancer

10,548 (22.85%)

2378 (22.20%)

8170 (23.04%)

 

 Rectum

29,225 (63.30%)

7159 (66.83%)

22,066 (62.24%)

 

Primary tumor sidedness

   

 < .001

 Right-sided

6393 (13.85%)

1175 (10.97%)

5218 (14.72%)

 

 Left-sided

39,773 (86.15%)

9537 (89.03%)

30,236 (85.28%)

 

Alcohol intake history

   

 < .001

 No

37,819 (81.92%)

4701 (43.89%)

33,118 (93.41%)

 

 Yes

8347 (18.08%)

6011 (56.11%)

2336 (6.59%)

 

Metastasis at diagnosis

   

 < .001

 No

15,523 (33.62%)

3440 (32.11%)

12,083 (34.08%)

 

 Yes

8567 (18.56%)

1889 (17.63%)

6678 (18.84%)

 

 Unknown

22,076 (47.82%)

5383 (50.25%)

16,693 (47.08%)

 

Family history

   

 < .001

 Yes

4264 (9.24%)

1256 (11.73%)

3008 (8.48%)

 

 No

41,902 (90.76%)

9456 (88.27%)

32,446 (91.52%)

 
  1. aP value of student’s t test to compare means