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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice

Fig. 5

Oxidative stress and inflammation were suppressed after cisplatin treatment in ABX group. a Western blot and quantification of PCNA and CYP2E1 in liver tissue. b Malondialdehyde (MDA) levels in mice liver. c Glutathione (GSH) levels in the liver homogenates after cisplatin treatment for 24 h. d Western blot and quantification of Nrf2 in the liver in cisplatin and cisplatin + ABX group after cisplatin treatment for 24 h. e Representative image and quantification of dihydroethidium (DHE) immunofluorescence staining in cisplatin and cisplatin + ABX group after cisplatin treatment for 24 h. f mRNA levels of key cytokines and chemokines in the liver. gi Western blot and quantification of p-JNK, p-p38, p-ERK in cisplatin and cisplatin + ABX group after cisplatin treatment for 24 h. The results are expressed as mean ± SEM. n = 3–12 per group. *P < 0.05

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