Fig. 4

Gut microbiota mediated the hepatotoxicity induced by cisplatin. a Representative liver morphology. b, c Plasma ALT and AST levels after 24 h cisplatin treatment. d H&E staining and histological score of liver tissue after 24 h cisplatin treatment. e Hepatic TUNEL staining and quantification of liver. The results are expressed as mean ± SEM. n = 5–12 per group. *P < 0.05. ALT alanine aminotransferase, AST aspartate aminotransferase, H&E Hematoxylin and Eosin, TUNEL terminal deoxynucleotidyl transferase dUTP nick end labelling