Fig. 3

Cisplatin altered the microbiota metabolites. a Principal Component Analysis (PCA) analysis of the metabolomics of faecal content. b Heat map shows the differential expression of metabolites between faecal content from the control and cisplatin-treated group. c Volcano plot indicates the increase in differentially expressed metabolites between the groups. d Network analysis indicates the correlation within and between metabolites up-regulated in both groups. e Comparison of Calenduloside B, Imperatorin, Lucidenic acid N, Physagulin F, Palmitic acid, and Ceramide between Control and Cisplatin groups. f Functional annotation and enrichment analysis of certain important differential metabolites. *P < 0.05, **P < 0.01, n = 5 per group