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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

Fig. 7

Molecular mechanism regarding HDAC4-mediated KLF5/Slug/CXCL12 axis in asthma. HDAC4 deacetylates KLF5 and increases its transcriptional activity. The deacetylated KLF5 promotes the expression of Slug in the promoter region of Slug, and then promotes the expression of CXCL12. This causes inflammation in bronchial epithelial cells and then induces the proliferation and migration of BSMCs, which leads to airway remodeling and thus aggravates the progression of asthma in mice

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Journal of Translational Medicine

ISSN: 1479-5876

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