Fig. 6

HDAC4 promotes airway inflammation and remodeling in asthmatic mice via regulation of the KLF5/Slug/CXCL12 axis. a The expression of HDAC4, KLF5, Slug, and CXCL12 in the lung tissues of mice with different treatments as determined by RT-qPCR. b The expression of HDAC4, KLF5, Ac-KLF5, Slug, and CXCL12 in the lung tissues of mice with different treatments. c The AHR in mice with different treatments as examined by methacholine challenge test. d The number of inflammatory cells in BALF of mice with different treatment. e The expression of IL-4, IL-5, and IL-13 in BALF of mice with different treatments as determined by ELISA. f The expression of α-SMA determined to measure the area of BSMCs in the lung tissues as examined by immunohistochemistry. *p < 0.05 vs. sh-NC. #p < 0.05 vs. sham-operated mice. These data were measurement data, expressed as mean ± standard deviation. Data among multiple groups were compared using one-way ANOVA, combined with Tukey’s post-hoc tests. Repeated measures ANOVA was performed for comparison on data at different time points among each group, combined with Bonferroni post-hoc tests. n = 6