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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

Fig. 1

Inhibition of HDAC4 attenuates airway inflammation and remodeling in asthmatic mice. a The silencing efficiency of HDAC4 as determined by RT-qPCR. b The silencing efficiency of HDAC4 as determined by Western blot assay. c The expression of HDAC4 in lung tissues of mice of mice with different treatment as determined by RT-qPCR. d The expression of HDAC4 in lung tissues of mice with different treatment as determined by Western blot assay. e The AHR in mice with different treatment as examined by methacholine challenge test. f The number of inflammatory cells in BALF of mice with different treatment. g The expression of IL-4, IL-5, and IL-13 in BALF of mice with different treatment as determined by ELISA. h The infiltration of inflammatory cells around the pulmonary bronchus of mice with different treatment as examined by HE staining (200 × ; 50 μm). i The expression of α-SMA determined to measure the area of BSMCs in the lung tissues as examined by immunohistochemistry. j The expression of hydroxyproline determined by Western blot assay in the lung tissues of mice with different treatment determined to examine the content of collagen in the lung tissues. *p < 0.05 vs. sh-NC. # p < 0.05 vs. sham-operated mice. These data were measurement data, expressed as mean ± standard deviation. Data between two groups were compared using unpaired t-test. Data among multiple groups were compared using one-way ANOVA, combined with Tukey’s post-hoc tests. Repeated measures ANOVA was performed for comparison on data at different time points among each group, combined with Bonferroni post-hoc tests. n = 6

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