Fig. 6

Bax and Bcl-2 expression in tumor tissues. Immunohistochemical staining indicated that Bax and Bcl-2 were mainly located in the cytoplasm, as evidenced by a clear brown-yellow diffuse distribution. a Some positive cells also exhibited brown particles in the cytoplasm or nuclear membrane (a and b). The expression levels of Bax were significantly higher in the IL-12 + BMSC, FYD, and FYD + IL-12 + BMSC groups following intervention compared with those of the model and BMSC groups (P < 0.05), whereas Bcl-2 expression was downregulated in the IL-12 + BMSC, FYD, and FYD + IL-12 + BMSC groups compared with that of the model and BMSC groups (P < 0.05). n = 3, ^#P < 0.05: Compared with the model group, ^*P < 0.05: Compared with the model group. BMSCs, bone marrow mesenchymal stem cells; IL-12 + BMSC, IL12-lentiviral-transfected BMSC; BMSC group, empty lentiviral vector-transfected BMSC group; FYD, FuzhengYiliu decoction; FYD + IL-12 + BMSC group, FYD treatment in IL-12 lentiviral-transfected BMSC group