Table 1 The expression analysis of the top 20 hub genes with the highest interaction degree
From: Cerebrospinal fluid cells immune landscape in multiple sclerosis
| Gene symbol | LogFC | P.Value | Adj. P.Value | Degree | Up/down-regulated |
|---|---|---|---|---|---|
| TLR2 | − 1.402720222 | 3.46E−05 | 0.000996373 | 38 | Down-regulated |
| CXCL8 | − 1.991659081 | 1.66E−05 | 0.000623919 | 38 | Down-regulated |
| IL1B | − 1.353392774 | 5.32E−06 | 0.000322284 | 38 | Down-regulated |
| FN1 | − 1.534988876 | 2.41E−05 | 0.000796163 | 34 | Down-regulated |
| CSF1R | − 1.212137423 | 5.36E−05 | 0.001354478 | 34 | Down-regulated |
| CD86 | − 1.086235688 | 0.000162393 | 0.002835159 | 32 | Down-regulated |
| CD163 | − 1.345148553 | 0.000387759 | 0.005193712 | 29 | Down-regulated |
| CD14 | − 1.899109363 | 7.01E−05 | 0.001644275 | 28 | Down-regulated |
| C3AR1 | − 1.333582312 | 6.91E−05 | 0.001631076 | 28 | Down-regulated |
| FOS | − 1.088599141 | 0.000691142 | 0.007925829 | 28 | Down-regulated |
| PTGS2 | − 1.585185487 | 5.97E−06 | 0.000348936 | 26 | Down-regulated |
| LILRB2 | − 1.260703038 | 2.49E−05 | 0.000803783 | 25 | Down-regulated |
| C1QB | − 1.677793359 | 0.000312054 | 0.00446939 | 23 | Down-regulated |
| MRC1 | − 1.399146821 | 0.000212776 | 0.00339139 | 23 | Down-regulated |
| C1QA | − 1.395713692 | 0.002766721 | 0.020479401 | 22 | Down-regulated |
| FCGR2A | − 1.580725252 | 7.77E−06 | 0.000400066 | 22 | Down-regulated |
| AIF1 | − 1.043775506 | 5.30E−07 | 7.89E−05 | 21 | Down-regulated |
| NLRP3 | − 1.127686613 | 3.53E−10 | 8.93E−07 | 21 | Down-regulated |
| CCL3 | − 1.113448799 | 0.000134268 | 0.00250386 | 21 | Down-regulated |
| MNDA | − 1.032416671 | 3.19E−05 | 0.000952134 | 20 | Down-regulated |