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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia

Fig. 1

PLXNB2 and circPLXNB2 expression in AML samples and the relationship between circPLXNB2 and clinical outcomes. a Representative images of PLXNB2 IHC staining in samples from patients with AML and healthy controls; b image software was used to measure the average optical density of the selected areas in PLXNB2 IHC-stained sections from patients with AML and healthy controls. EMI, n = 4; non-EMI, n = 4; control, n = 4 samples. The original magnification was 400×. The expression of the PLXNB2 mRNA (c), circPLXNB2 (d) and hsa_circ_0004520 (e) in the samples was detected using qRT-PCR. Control, n = 15; EMI, n = 24; non-EMI, n = 16; whole AML = EMI + non-EMI, n = 40 samples. f ROC and AUC analysis of circPLXNB2 expression in 40 patients with AML. Kaplan–Meier analyses of OS (g) and LFS (h) in patients with AML stratified according to circPLXNB2 expression levels (n = 40). i The correlation between the expression of circPLXNB2 and the PLXNB2 mRNA was examined using Pearson’s correlation test. Each experiment was repeated three times. *P < 0.05, **P < 0.01, and ***P < 0.001. EMI extramedullary infiltration, AUC area under the ROC curve, OS overall survival, LFS Leukaemia-free survival, ns not significant

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