Fig. 5

Reanalysis of the genes in the 13 OAMs combined with clinical microarray data. a–d The mRNA levels of CYP2B6, PI3, MMP2 and TIMP2 among different groups. # denotes statistical significance (P < 0.05) between the CHB and HCC groups; & denotes statistical significance (P < 0.05) between the cirrhosis and HCC groups; and * denotes statistical significance (P < 0.05) between the CHB and cirrhosis groups. e–g The correlation coefficient between the 11 pairs of genes in CHB, cirrhosis, and HCC. All gene pairs were highly correlated in the three disease states (r > 0.63). In the matrix, the red circles indicate a positive correlation, while the blue circles indicate a negative correlation. The larger a circle is, the stronger the correlation. h The changing trend of the correlation coefficient between the 11 pairs of genes in the three pathologic stages (CHB, cirrhosis, and HCC). The underlined gene pairs indicate that the changing trends in the correlation of 6 gene pairs in the three disease states were consistent with the disease states indicated by the OAMs that the gene pairs belong to