Fig. 3

Topological changes in the 13 potential OAMs. The modules are color coded; green nodes and edges denote cirrhosis modules, blue nodes and edges denote HCC modules, and purple nodes and edges denote CHB modules. The overlapping nodes and edges between modules are highlighted in red (cirrhosis vs. HCC), yellow (CHB vs. HCC), gray (CHB vs. cirrhosis) and orange (CHB vs. cirrhosis vs. HCC), respectively. a Node–node change; b Node-module change; c Module-module change. The changing characteristics of the module structures in each OAM are listed below the modules. “↑” denotes that the number of nodes or edges increases. “↓” denotes that the number of nodes or edges decreases