Fig. 2

Different levels of similarities between the modules in the CHB, cirrhosis and HCC groups. a Six levels of similarities reflecting the degree of overlap between modules in the CHB, cirrhosis and HCC groups, including S_ne > 0, > 20%, > 40%, > 60%, > 80%, and = 100%. Each Venn diagram represents a level of similarity. The green circle denotes the number of modules in the CHB group. The blue circle denotes the number of modules in the cirrhosis group. The red circle denotes the number of modules in the HCC group. Gray arrows indicate the progression of the disease. b The changing trends of the number of overlapping modules between the CHB and cirrhosis groups (blue line), the cirrhosis and HCC groups (gray line), the CHB and HCC groups (green line), and among the three groups (red line). c Examples of DEMs. AM_CHB15, AM_C14, and AM_HCC8 were DEMs in the CHB, cirrhosis and HCC groups, respectively. d Examples of CAMs. The area in the blue solid line represents AM_HCC18. The green solid line area represents AM_C7. e Examples of TAMs. The green solid line area represents AM_C5. The purple area indicates AM_CHB10