TY - JOUR AU - Pineau, P. AU - Volinia, S. AU - McJunkin, K. AU - Marchio, A. AU - Battiston, C. AU - Terris, B. PY - 2010 DA - 2010// TI - miR-221 overexpression contributes to liver tumorigenesis JO - Proc Natl Acad Sci USA VL - 107 UR - https://doi.org/10.1073/pnas.0907904107 DO - 10.1073/pnas.0907904107 ID - Pineau2010 ER - TY - JOUR AU - Mah, W. C. AU - Lee, C. G. PY - 2014 DA - 2014// TI - DNA methylation: potential riskin hepatocellular carcinoma JO - Biomark Res VL - 2 UR - https://doi.org/10.1186/2050-7771-2-5 DO - 10.1186/2050-7771-2-5 ID - Mah2014 ER - TY - JOUR AU - Huang, J. AU - Deng, Q. AU - Wang, Q. AU - Li, K. Y. AU - Dai, J. H. AU - Li, N. PY - 2012 DA - 2012// TI - Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma JO - Nat Genet VL - 44 UR - https://doi.org/10.1038/ng.2391 DO - 10.1038/ng.2391 ID - Huang2012 ER - TY - JOUR AU - Ji, J. AU - Yamashita, T. AU - Budhu, A. AU - Forgues, M. AU - Jia, H. L. AU - Li, C. PY - 2009 DA - 2009// TI - Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells JO - Hepatology VL - 50 UR - https://doi.org/10.1002/hep.22989 DO - 10.1002/hep.22989 ID - Ji2009 ER - TY - JOUR AU - Jiang, Y. F. AU - He, B. AU - Li, N. P. AU - Ma, J. AU - Gong, G. Z. AU - Zhang, M. PY - 2011 DA - 2011// TI - The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways JO - Cell Biol Int VL - 35 UR - https://doi.org/10.1042/CBI20110102 DO - 10.1042/CBI20110102 ID - Jiang2011 ER - TY - JOUR AU - Diao, J. AU - Pantua, H. AU - Ngu, H. AU - Komuves, L. AU - Diehl, L. AU - Schaefer, G. PY - 2012 DA - 2012// TI - Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry JO - J Virol VL - 86 UR - https://doi.org/10.1128/JVI.00750-12 DO - 10.1128/JVI.00750-12 ID - Diao2012 ER - TY - JOUR AU - Tsuchiya, N. AU - Sawada, Y. AU - Endo, I. AU - Saito, K. AU - Uemura, Y. AU - Nakatsura, T. PY - 2015 DA - 2015// TI - Biomarkers for the early diagnosis of hepatocellular carcinoma JO - World J Gastroenterol VL - 21 UR - https://doi.org/10.3748/wjg.v21.i37.10573 DO - 10.3748/wjg.v21.i37.10573 ID - Tsuchiya2015 ER - TY - JOUR AU - Li, L. AU - Chen, J. AU - Chen, X. AU - Tang, J. AU - Guo, H. AU - Wang, X. PY - 2016 DA - 2016// TI - Serum miRNAs as predictive and preventive riskfor pre-clinical hepatocellular carcinoma JO - Cancer Lett VL - 373 UR - https://doi.org/10.1016/j.canlet.2016.01.028 DO - 10.1016/j.canlet.2016.01.028 ID - Li2016 ER - TY - JOUR AU - He, Y. AU - Dang, Q. AU - Li, J. AU - Zhang, Q. AU - Yu, X. AU - Xue, M. PY - 2020 DA - 2020// TI - Prediction of hepatocellular carcinoma prognosis based on expression of an immune-related gene set JO - Aging VL - 12 UR - https://doi.org/10.18632/aging.102669 DO - 10.18632/aging.102669 ID - He2020 ER - TY - JOUR AU - Kim, D. W. AU - Talati, C. AU - Kim, R. PY - 2017 DA - 2017// TI - Hepatocellular carcinoma (HCC): beyond sorafenib-chemotherapy JO - J Gastrointest Oncol VL - 8 UR - https://doi.org/10.21037/jgo.2016.09.07 DO - 10.21037/jgo.2016.09.07 ID - Kim2017 ER - TY - JOUR AU - Chen, L. AU - Liu, R. AU - Liu, Z. P. AU - Li, M. AU - Aihara, K. PY - 2012 DA - 2012// TI - Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers JO - Sci Rep VL - 2 UR - https://doi.org/10.1038/srep00342 DO - 10.1038/srep00342 ID - Chen2012 ER - TY - JOUR AU - Wang, Z. AU - Liu, J. AU - Yu, Y. AU - Chen, Y. AU - Wang, Y. PY - 2012 DA - 2012// TI - Modular pharmacology: the next paradigm in drug discovery JO - Expert Opin Drug Discov VL - 7 UR - https://doi.org/10.1517/17460441.2012.692673 DO - 10.1517/17460441.2012.692673 ID - Wang2012 ER - TY - JOUR AU - Barabasi, A. L. AU - Gulbahce, N. AU - Loscalzo, J. PY - 2011 DA - 2011// TI - Network medicine: a network-based approach to human disease JO - Nat Rev Genet VL - 12 UR - https://doi.org/10.1038/nrg2918 DO - 10.1038/nrg2918 ID - Barabasi2011 ER - TY - JOUR AU - Chen, Y. Y. AU - Yu, Y. N. AU - Zhang, Y. Y. AU - Li, B. AU - Liu, J. AU - Li, D. F. PY - 2016 DA - 2016// TI - Quantitative determination of flexible pharmacological mechanisms based on topological variation in mice anti-ischemic modular networks JO - PLoS ONE VL - 11 UR - https://doi.org/10.1371/journal.pone.0158379 DO - 10.1371/journal.pone.0158379 ID - Chen2016 ER - TY - JOUR AU - Nussinov, R. AU - Ma, B. AU - Tsai, C. J. AU - Csermely, P. PY - 2013 DA - 2013// TI - Allosteric conformational barcodes direct signaling in the cell JO - Structure VL - 21 UR - https://doi.org/10.1016/j.str.2013.06.002 DO - 10.1016/j.str.2013.06.002 ID - Nussinov2013 ER - TY - JOUR AU - Nussinov, R. AU - Tsai, C. J. AU - Ma, B. PY - 2013 DA - 2013// TI - The Underappreciated Role of Allostery in the Cellular Network JO - Annu Rev Biophys VL - 42 UR - https://doi.org/10.1146/annurev-biophys-083012-130257 DO - 10.1146/annurev-biophys-083012-130257 ID - Nussinov2013 ER - TY - JOUR AU - Nussinov, R. AU - Tsai, C. J. PY - 2013 DA - 2013// TI - Allostery in disease and in drug discovery JO - Cell VL - 153 UR - https://doi.org/10.1016/j.cell.2013.03.034 DO - 10.1016/j.cell.2013.03.034 ID - Nussinov2013 ER - TY - JOUR AU - Bader, G. D. AU - Hogue, C. W. PY - 2003 DA - 2003// TI - An automated method for finding molecular complexes in large protein interaction networks JO - BMC Bioinformatics VL - 4 UR - https://doi.org/10.1186/1471-2105-4-2 DO - 10.1186/1471-2105-4-2 ID - Bader2003 ER - TY - JOUR AU - Xie, C. AU - Mao, X. AU - Huang, J. AU - Ding, Y. AU - Wu, J. AU - Dong, S. PY - 2011 DA - 2011// TI - KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases JO - Nucleic Acids Res. VL - 39 UR - https://doi.org/10.1093/nar/gkr483 DO - 10.1093/nar/gkr483 ID - Xie2011 ER - TY - JOUR AU - Association, C. M. PY - 2001 DA - 2001// TI - Chronic hepatitis B prevention and treatment guidelines JO - Chinese J Infect Dis VL - 19 ID - Association2001 ER - TY - JOUR AU - Zhang, Y. X. AU - Wei, B. H. PY - 1994 DA - 1994// TI - Standard of clinic diagnosis, syndrome differentiation and assessing curative effect on hepatocirrhosis JO - Chin J Integrated Trad West Med Gastro-spleen VL - 14 ID - Zhang1994 ER - TY - JOUR AU - Yang, B. H. PY - 2001 DA - 2001// TI - Chinese Society of Liver Cancer: clinical diagnosis and staging criteria for primary hepatocellular carcinoma JO - Zhongguo Ganzangbing Zazhi VL - 9 ID - Yang2001 ER - TY - JOUR AU - Lu, Y. Y. AU - Chen, Q. L. AU - Guan, Y. AU - Guo, Z. Z. AU - Zhang, H. AU - Zhang, W. PY - 2014 DA - 2014// TI - Transcriptional profiling and co-expression network analysis identifies potential biomarkers to differentiate chronic hepatitis B and the caused cirrhosis JO - Mol Biosyst VL - 10 UR - https://doi.org/10.1039/C3MB70474B DO - 10.1039/C3MB70474B ID - Lu2014 ER - TY - JOUR AU - Lu, Y. Y. AU - Chen, Q. L. AU - Guan, Y. AU - Guo, Z. Z. AU - Zhang, H. AU - Zhang, W. PY - 2014 DA - 2014// TI - Study of ZHENG differentiation in hepatitis B-caused cirrhosis: a transcriptional profiling analysis JO - BMC Complement Altern Med VL - 14 UR - https://doi.org/10.1186/1472-6882-14-371 DO - 10.1186/1472-6882-14-371 ID - Lu2014 ER - TY - JOUR AU - Guo, Z. AU - Yu, S. AU - Guan, Y. AU - Li, Y. Y. AU - Lu, Y. Y. AU - Zhang, H. PY - 2012 DA - 2012// TI - Molecular mechanisms of same TCM syndrome for different diseases and different TCM syndrome for same disease in chronic hepatitis B and liver cirrhosis JO - Evid Based Complement Alternat Med VL - 2012 UR - https://doi.org/10.1155/2012/120350 DO - 10.1155/2012/120350 ID - Guo2012 ER - TY - CHAP AU - Gertler, R. AU - Rosenberg, R. AU - Fuehrer, K. AU - Dahm, M. AU - Nekarda, H. AU - Siewert, J. R. ED - Allgayer, H. ED - Heiss, M. M. ED - Schildberg, F. W. PY - 2003 DA - 2003// TI - Detection of circulating tumor cells in blood using an optimized density gradient centrifugation BT - Molecular staging of cancer. Recent results in cancer research PB - Springer CY - Berlin UR - https://doi.org/10.1007/978-3-642-59349-9_13 DO - 10.1007/978-3-642-59349-9_13 ID - Gertler2003 ER - TY - JOUR AU - Houtao, D. PY - 2019 DA - 2019// TI - Interpreting tree ensembles with inTrees JO - Int J Data Sci Anal VL - 7 UR - https://doi.org/10.1007/s41060-018-0144-8 DO - 10.1007/s41060-018-0144-8 ID - Houtao2019 ER - TY - JOUR PY - 2019 DA - 2019// TI - The guidelines of prevention and treatment for chronic hepatitis B 2019 version) (Article in Chinese) JO - Zhonghua Gan Zang Bing Za Zhi VL - 27 ID - ref28 ER - TY - JOUR AU - Zhou, F. AU - Shang, W. AU - Yu, X. AU - Tian, J. PY - 2018 DA - 2018// TI - Glypican-3: a promising biomarker for hepatocellular carcinoma diagnosis and treatment JO - Med Res Rev VL - 38 UR - https://doi.org/10.1002/med.21455 DO - 10.1002/med.21455 ID - Zhou2018 ER - TY - JOUR AU - Bhattacharya, S. AU - Steele, R. AU - Shrivastava, S. AU - Chakraborty, S. AU - Bisceglie, A. M. AU - Ray, R. B. PY - 2016 DA - 2016// TI - Serum miR-30e and miR-223 as novel noninvasive biomarkers for hepatocellular carcinoma JO - Am J Pathol VL - 186 UR - https://doi.org/10.1016/j.ajpath.2015.10.003 DO - 10.1016/j.ajpath.2015.10.003 ID - Bhattacharya2016 ER - TY - JOUR AU - Brodeur, C. M. AU - Thibault, P. AU - Durand, M. AU - Perreault, J. P. AU - Bisaillon, M. PY - 2019 DA - 2019// TI - Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers JO - Genes Cancer VL - 10 UR - https://doi.org/10.18632/genesandcancer.190 DO - 10.18632/genesandcancer.190 ID - Brodeur2019 ER - TY - JOUR PY - 2012 DA - 2012// TI - EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma JO - J Hepatol VL - 56 UR - https://doi.org/10.1016/j.jhep.2011.12.001 DO - 10.1016/j.jhep.2011.12.001 ID - ref32 ER - TY - JOUR AU - Li, B. AU - Liu, J. AU - Zhang, Y. Y. AU - Wang, P. Q. AU - Yu, Y. N. AU - Kang, R. X. PY - 2016 DA - 2016// TI - Quantitative identification of compound-dependent on-modules and differential allosteric modules from homologous ischemic networks JO - CPT Pharmacometrics Syst Pharmacol VL - 5 UR - https://doi.org/10.1002/psp4.12127 DO - 10.1002/psp4.12127 ID - Li2016 ER - TY - JOUR AU - Yu, Y. AU - Zhang, X. AU - Li, B. AU - Zhang, Y. AU - Liu, J. AU - Li, H. PY - 2016 DA - 2016// TI - Entropy-based divergent and convergent modular pattern reveals additive and synergistic anticerebral ischemia mechanisms JO - Exp Biol Med VL - 241 UR - https://doi.org/10.1177/1535370216662361 DO - 10.1177/1535370216662361 ID - Yu2016 ER - TY - JOUR AU - Tokusashi, Y. AU - Asai, K. AU - Tamakawa, S. AU - Yamamoto, M. AU - Yoshie, M. AU - Yaginuma, Y. PY - 2005 DA - 2005// TI - Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components JO - Int J Cancer VL - 114 UR - https://doi.org/10.1002/ijc.20685 DO - 10.1002/ijc.20685 ID - Tokusashi2005 ER - TY - JOUR AU - Chisari, F. V. AU - Isogawa, M. AU - Wieland, S. F. PY - 2010 DA - 2010// TI - Pathogenesis of hepatitis B virus infectionPathogenèse de l’infection par le virus de l’hépatite B JO - Pathol Biol VL - 58 UR - https://doi.org/10.1016/j.patbio.2009.11.001 DO - 10.1016/j.patbio.2009.11.001 ID - Chisari2010 ER - TY - JOUR AU - Arzumanyan, A. AU - Reis, H. M. AU - Feitelson, M. A. PY - 2013 DA - 2013// TI - Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma JO - Nat Rev Cancer VL - 13 UR - https://doi.org/10.1038/nrc3449 DO - 10.1038/nrc3449 ID - Arzumanyan2013 ER - TY - JOUR AU - Whittaker, S. AU - Marais, R. AU - Zhu, A. X. PY - 2010 DA - 2010// TI - The role of signaling pathways in the development and treatment of hepatocellular carcinoma JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.236 DO - 10.1038/onc.2010.236 ID - Whittaker2010 ER - TY - JOUR AU - Yang, P. AU - Li, Q. J. AU - Feng, Y. AU - Zhang, Y. AU - Markowitz, G. J. AU - Ning, S. PY - 2012 DA - 2012// TI - TGF-b-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma JO - Cancer Cell VL - 22 UR - https://doi.org/10.1016/j.ccr.2012.07.023 DO - 10.1016/j.ccr.2012.07.023 ID - Yang2012 ER - TY - JOUR AU - Zhang, Y. AU - Qiu, Z. AU - Wei, L. AU - Tang, R. AU - Lian, B. AU - Zhao, Y. PY - 2014 DA - 2014// TI - Integrated analysis of mutation data from various sources identifies key genes and signaling pathways in hepatocellular carcinoma JO - PLoS ONE VL - 9 UR - https://doi.org/10.1371/journal.pone.0100854 DO - 10.1371/journal.pone.0100854 ID - Zhang2014 ER - TY - JOUR AU - Bouchard, M. J. AU - Wang, L. AU - Schneider, R. J. PY - 2006 DA - 2006// TI - Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication JO - J Virol VL - 80 UR - https://doi.org/10.1128/JVI.80.9.4406-4414.2006 DO - 10.1128/JVI.80.9.4406-4414.2006 ID - Bouchard2006 ER - TY - JOUR AU - Lara-Pezzi, E. AU - Roche, S. AU - Andrisani, O. M. AU - Sánchez-Madrid, F. AU - López-Cabrera, M. PY - 2001 DA - 2001// TI - The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner JO - Oncogene VL - 20 UR - https://doi.org/10.1038/sj.onc.1204451 DO - 10.1038/sj.onc.1204451 ID - Lara-Pezzi2001 ER - TY - JOUR AU - Ito, Y. AU - Takeda, T. AU - Sakon, M. AU - Tsujimoto, M. AU - Higashiyama, S. AU - Noda, K. PY - 2001 DA - 2001// TI - Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma JO - Br J Cancer VL - 84 UR - https://doi.org/10.1054/bjoc.2000.1580 DO - 10.1054/bjoc.2000.1580 ID - Ito2001 ER - TY - JOUR AU - Liu, J. AU - Ahiekpor, A. AU - Li, L. AU - Li, X. AU - Arbuthnot, P. AU - Kew, M. PY - 2009 DA - 2009// TI - Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer JO - Int J Cancer VL - 125 UR - https://doi.org/10.1002/ijc.24580 DO - 10.1002/ijc.24580 ID - Liu2009 ER - TY - JOUR AU - Isogawa, M. AU - Robek, M. D. AU - Furuichi, Y. AU - Chisari, F. V. PY - 2005 DA - 2005// TI - Toll-like receptor signaling inhibits hepatitis B virus replication in vivo JO - J Virol VL - 79 UR - https://doi.org/10.1128/JVI.79.11.7269-7272.2005 DO - 10.1128/JVI.79.11.7269-7272.2005 ID - Isogawa2005 ER - TY - JOUR AU - Huang, C. F. AU - Lin, S. S. AU - Ho, Y. C. AU - Chen, F. L. AU - Yang, C. C. PY - 2006 DA - 2006// TI - The immune response induced by hepatitis B virus principal antigens JO - Cell Mol Immunol VL - 3 ID - Huang2006 ER - TY - JOUR AU - Gao, B. AU - Radaeva, S. AU - Park, O. PY - 2009 DA - 2009// TI - Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases JO - J Leukoc Biol VL - 86 UR - https://doi.org/10.1189/JLB.0309135 DO - 10.1189/JLB.0309135 ID - Gao2009 ER - TY - JOUR AU - Beyoğlu, D. AU - Imbeaud, S. AU - Maurhofer, O. AU - Bioulac-Sage, P. AU - Zucman-Rossi, J. AU - Dufour, J. F. PY - 2013 DA - 2013// TI - Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification JO - Hepatology VL - 58 UR - https://doi.org/10.1002/hep.26350 DO - 10.1002/hep.26350 ID - Beyoğlu2013 ER - TY - JOUR AU - Yuan, J. M. AU - Gao, Y. T. AU - Ong, C. N. AU - Ross, R. K. AU - Yu, M. C. PY - 2006 DA - 2006// TI - Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma JO - J Natl Cancer Inst VL - 98 UR - https://doi.org/10.1093/jnci/djj104 DO - 10.1093/jnci/djj104 ID - Yuan2006 ER - TY - JOUR AU - Liu, H. AU - Lou, G. AU - Li, C. AU - Wang, X. AU - Cederbaum, A. I. AU - Gan, L. PY - 2014 DA - 2014// TI - HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells JO - PLoS ONE VL - 9 UR - https://doi.org/10.1371/journal.pone.0107913 DO - 10.1371/journal.pone.0107913 ID - Liu2014 ER - TY - BOOK AU - Kuhn, M. AU - Johnson, K. PY - 2013 DA - 2013// TI - Applied Predictive Modeling PB - Springer-Verlag CY - New York UR - https://doi.org/10.1007/978-1-4614-6849-3 DO - 10.1007/978-1-4614-6849-3 ID - Kuhn2013 ER - TY - BOOK AU - Hosmer, D. W. AU - Lemeshow, S. AU - Sturdivant, R. X. PY - 2013 DA - 2013// TI - Applied logistic regression PB - Wiley CY - New Jersey UR - https://doi.org/10.1002/9781118548387 DO - 10.1002/9781118548387 ID - Hosmer2013 ER - TY - JOUR AU - Wong, V. W. AU - Yu, J. AU - Cheng, A. S. AU - Wong, G. L. AU - Chan, H. Y. AU - Chu, E. S. PY - 2009 DA - 2009// TI - High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B JO - Int J Cancer VL - 124 UR - https://doi.org/10.1002/ijc.24281 DO - 10.1002/ijc.24281 ID - Wong2009 ER - TY - JOUR AU - Porta, C. AU - Amici, M. AU - Quaglini, S. AU - Paglino, C. AU - Tagliani, F. AU - Boncimino, A. PY - 2008 DA - 2008// TI - Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma JO - Ann Oncol VL - 19 UR - https://doi.org/10.1093/annonc/mdm448 DO - 10.1093/annonc/mdm448 ID - Porta2008 ER -