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Table 3 Haplotype frequencies and association with NS occurrence and its subtypes

From: Prediction of steroid resistance and steroid dependence in nephrotic syndrome children

Gene

SNPs

Haplotype

Frequency

SR vs. SS

SR vs. PSS

SR vs. SD

SD vs. PSS

NS vs. C

NS

SR

SS

SD

PSS

C

OR [CI 95%]

p-value

OR [CI 95%]

p-value

OR [CI 95%]

p-value

OR [CI 95%]

p-value

OR [CI 95%]

p-value

ABCB1

rs1922240

AAC

0.33

0.381

0.305

0.19

0.398

0.43

1.4 [0.8–2.4]

0.2102

0.9 [0.5–1.7]

0.816

2.7 [1.3–5.6]

0.0098**

0.4 [0.2–0.8]

0.0077**

0.7 [0.4–1.1]

0.0685

 

rs1045642

AGT

0.187

0.213

0.16

0.262

0.077

0.224

1.4 [0.7–2.7]

0.2818

3.3 [1.3–8.4]

0.0111*

0.8 [0.4–1.6]

0.4723

4.2 [1.6–11.5]

0.0028**

0.8 [0.5–1.4]

0.411

 

rs2235048

GAC

0.174

0.185

0.153

0.165

0.14

0.143

1.2 [0.6–2.4]

0.5004

1.4 [0.6–3.2]

0.4102

1.2 [0.5–2.7]

0.7432

1.2 [0.5–3.1]

0.676

1.3 [0.7–2.4]

0.455

  

GGT

0.293

0.211

0.361

0.335

0.385

0.203

0.5 [0.3–0.8]

0.0106*

0.4 [0.2–0.8]

0.0093**

0.5 [0.3–1.1]

0.764

0.8 [0.4–1.6]

0.5364

1.7 [1–2.9]

0.0742

  

AGC

0.016

0

0.021

0.048

0

0

0.001 [0–0.2]

0.2186

–

–

0 [0–0.01]

0.0347*

–

0.0468*

–

0.186

  

GGC

0

0.009

0

0

0

0

148.5 [6.1–3605]

0.3602

–

0.3843

–

0.4436

–

–

–

–

          

0.0625†

 

0.0204*

 

0.0223*

 

0.0022**

 

0.1436

CD73

rs9444348

AG

0.524

0.594

0.472

0.468

0.475

0.464

1.7 [1–2.8]

0.0462*

1.7 [0.9–3]

0.1058

1.7 [0.9–3.2]

0.097

1 [0.5–1.9]

0.9315

1.3 [0.8–2]

0.2913

 

rs4431401

GA

0.447

0.396

0.486

0.484

0.487

0.473

0.7 [0.4–1.2]

0.1797

0.7 [0.4–1.3]

0.214

0.7 [0.4–1.3]

0.2904

1 [0.5–1.9]

0.9658

0.9 [0.6–1.4]

0.656

  

GG

0.024

0

0.042

0.048

0.038

0.064

–

0.0322*

–

0.0445*

–

0.0223*

1.3 [0.3–6.7]

0.7491

0.4 [0.1–1.1]

0.0668

  

AA

0.004

0.009

0

0

0

0

–

0.2462

–

0.3838

–

0.4431

–

–

–

0.499

            

0.0498*

 

0.0562

 

0.9499

 

0.2259

MIF

rs5844572

5AG

0

0

0

0.017

0

0

–

–

–

–

0.01 [0–0.3]

0.2553

753.4 [30.7–18,466.1]

0.3534

–

–

 

rs2070767

5AT

0.266

0.264

0.267

0.273

0.25

0.236

1 [0.6–1.8]

0.9877

1.1 [0.6–2.1]

0.787

1 [0.5–2]

0.9294

1.2 [0.5–2.5]

0.7077

1.1 [0.7–1.9]

0.6302

 

rs2000466

5GT

0.02

0.01

0.028

0.032

0.025

0.027

0.3 [0.04–3]

0.3062

0.4 [0.04–4.2]

0.413

0.3 [0.03–3.3]

0.2933

1.3 [0.2–9.7]

0.7819

0.7 [0.2–3.1]

0.6744

  

6GG

0.053

0.047

0.056

0.031

0.062

0.027

0.8 [0.3–2.7]

0.7721

0.8 [0.2–2.7]

0.668

1.6 [0.3–8.4]

0.6044

0.5 [0.1–2.7]

0.4059

1.9 [0.5–6.9]

0.3073

  

6GT

0.52

0.518

0.521

0.565

0.5

0.509

1 [0.6–1.7]

0.9643

1.1 [0.6–2]

0.7243

0.9 [0.5–1.6]

0.6081

1.4 [0.7–2.7]

0.3755

1 [0.6–1.6]

0.9871

  

7GG

0.129

0.132

0.127

0.081

0.163

0.172

1.1 [0.5–2.2]

0.8827

0.8 [0.3–1.8]

0.5806

1.8 [0.6–5.1]

0.2999

0.5 [0.2–1.4]

0.1563

0.7 [0.4–1.3]

0.2365

  

6AT

0.008

0.019

0

0

0

0.009

–

0.0983

–

0.214

–

0.2737

–

–

0.9 [0.1–9.6]

0.9202

  

7GT

0.004

0.01

0

0

0

0.009

–

0.2367

–

0.3741

–

0.4338

–

–

0.5 [0.03–6.9]

0.5613

  

7AT

0

0

0

0

0

0.009

–

–

–

–

–

–

–

–

–

0.1327

          

0.5137

 

0.7402

 

0.545

 

0.505

 

0.6419

  1. †The last p-value number in a column for a haplotype is a global p-value. 5, 6 and 7 numbers in MIF haplotypes refer to the number of CATT repeats. Lowest frequency threshold was set to 0.009. Significant results are shown in bold; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001
  2. NS nephrotic syndrome, SR steroid resistant, SS steroid sensitive, SD steroid dependent, PSS primarily steroid sensitive, C controls
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Journal of Translational Medicine

ISSN: 1479-5876

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