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Table 3 Haplotype frequencies and association with NS occurrence and its subtypes

From: Prediction of steroid resistance and steroid dependence in nephrotic syndrome children

Gene SNPs Haplotype Frequency SR vs. SS SR vs. PSS SR vs. SD SD vs. PSS NS vs. C
NS SR SS SD PSS C OR [CI 95%] p-value OR [CI 95%] p-value OR [CI 95%] p-value OR [CI 95%] p-value OR [CI 95%] p-value
ABCB1 rs1922240 AAC 0.33 0.381 0.305 0.19 0.398 0.43 1.4 [0.8–2.4] 0.2102 0.9 [0.5–1.7] 0.816 2.7 [1.3–5.6] 0.0098** 0.4 [0.2–0.8] 0.0077** 0.7 [0.4–1.1] 0.0685
  rs1045642 AGT 0.187 0.213 0.16 0.262 0.077 0.224 1.4 [0.7–2.7] 0.2818 3.3 [1.3–8.4] 0.0111* 0.8 [0.4–1.6] 0.4723 4.2 [1.6–11.5] 0.0028** 0.8 [0.5–1.4] 0.411
  rs2235048 GAC 0.174 0.185 0.153 0.165 0.14 0.143 1.2 [0.6–2.4] 0.5004 1.4 [0.6–3.2] 0.4102 1.2 [0.5–2.7] 0.7432 1.2 [0.5–3.1] 0.676 1.3 [0.7–2.4] 0.455
   GGT 0.293 0.211 0.361 0.335 0.385 0.203 0.5 [0.3–0.8] 0.0106* 0.4 [0.2–0.8] 0.0093** 0.5 [0.3–1.1] 0.764 0.8 [0.4–1.6] 0.5364 1.7 [1–2.9] 0.0742
   AGC 0.016 0 0.021 0.048 0 0 0.001 [0–0.2] 0.2186 0 [0–0.01] 0.0347* 0.0468* 0.186
   GGC 0 0.009 0 0 0 0 148.5 [6.1–3605] 0.3602 0.3843 0.4436
           0.0625   0.0204*   0.0223*   0.0022**   0.1436
CD73 rs9444348 AG 0.524 0.594 0.472 0.468 0.475 0.464 1.7 [1–2.8] 0.0462* 1.7 [0.9–3] 0.1058 1.7 [0.9–3.2] 0.097 1 [0.5–1.9] 0.9315 1.3 [0.8–2] 0.2913
  rs4431401 GA 0.447 0.396 0.486 0.484 0.487 0.473 0.7 [0.4–1.2] 0.1797 0.7 [0.4–1.3] 0.214 0.7 [0.4–1.3] 0.2904 1 [0.5–1.9] 0.9658 0.9 [0.6–1.4] 0.656
   GG 0.024 0 0.042 0.048 0.038 0.064 0.0322* 0.0445* 0.0223* 1.3 [0.3–6.7] 0.7491 0.4 [0.1–1.1] 0.0668
   AA 0.004 0.009 0 0 0 0 0.2462 0.3838 0.4431 0.499
             0.0498*   0.0562   0.9499   0.2259
MIF rs5844572 5AG 0 0 0 0.017 0 0 0.01 [0–0.3] 0.2553 753.4 [30.7–18,466.1] 0.3534
  rs2070767 5AT 0.266 0.264 0.267 0.273 0.25 0.236 1 [0.6–1.8] 0.9877 1.1 [0.6–2.1] 0.787 1 [0.5–2] 0.9294 1.2 [0.5–2.5] 0.7077 1.1 [0.7–1.9] 0.6302
  rs2000466 5GT 0.02 0.01 0.028 0.032 0.025 0.027 0.3 [0.04–3] 0.3062 0.4 [0.04–4.2] 0.413 0.3 [0.03–3.3] 0.2933 1.3 [0.2–9.7] 0.7819 0.7 [0.2–3.1] 0.6744
   6GG 0.053 0.047 0.056 0.031 0.062 0.027 0.8 [0.3–2.7] 0.7721 0.8 [0.2–2.7] 0.668 1.6 [0.3–8.4] 0.6044 0.5 [0.1–2.7] 0.4059 1.9 [0.5–6.9] 0.3073
   6GT 0.52 0.518 0.521 0.565 0.5 0.509 1 [0.6–1.7] 0.9643 1.1 [0.6–2] 0.7243 0.9 [0.5–1.6] 0.6081 1.4 [0.7–2.7] 0.3755 1 [0.6–1.6] 0.9871
   7GG 0.129 0.132 0.127 0.081 0.163 0.172 1.1 [0.5–2.2] 0.8827 0.8 [0.3–1.8] 0.5806 1.8 [0.6–5.1] 0.2999 0.5 [0.2–1.4] 0.1563 0.7 [0.4–1.3] 0.2365
   6AT 0.008 0.019 0 0 0 0.009 0.0983 0.214 0.2737 0.9 [0.1–9.6] 0.9202
   7GT 0.004 0.01 0 0 0 0.009 0.2367 0.3741 0.4338 0.5 [0.03–6.9] 0.5613
   7AT 0 0 0 0 0 0.009 0.1327
           0.5137   0.7402   0.545   0.505   0.6419
  1. The last p-value number in a column for a haplotype is a global p-value. 5, 6 and 7 numbers in MIF haplotypes refer to the number of CATT repeats. Lowest frequency threshold was set to 0.009. Significant results are shown in bold; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001
  2. NS nephrotic syndrome, SR steroid resistant, SS steroid sensitive, SD steroid dependent, PSS primarily steroid sensitive, C controls