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Table 1 Demographics and baseline laboratory characteristics of individuals used in this study

From: Prediction of steroid resistance and steroid dependence in nephrotic syndrome children

Parameters

Individuals

Single comparison p-value

Multiple comparison OR[95% CI]/ p-value

NS

SR

SS

SD

PSS

C

Demographics

n = 124

n = 53

n = 71

n = 31

n = 40

n = 55

 

 Male (%)

66 (53.2%)

30 (56.6%)

36(50.7%)

14 (45.2%)

22 (55%)

31 (56.4%)

 

 Female (%)

58 (46.8%)

23 (43.4%)

35 (49.3%)

17 (54.8%)

18 (45%)

24 (43.6%)

0.8263

 AOO [years]

5 ± 4.23

5.4 ± 4.85

4.71 ± 3.72

4.45 ± 3.95

4.9 ± 3.57

0.3687

Histology

      

0.0516

 FSGS

16 (13%)

13 (24%)

3 (4%)

3 (10%)

0 (0%)

SR vs.SS: 4.6 [1.2–17.8] p = 0.0263*

 MPGN

25 (20%)

13 (24%)

12 (17%)

9 (29%)

3 (7,5%)

SR vs.PSS: 12 [0.7–21.6] p = 0.093

 MCD

37 (30%)

17 (32%)

20 (28%)

10 (32%)

10 (25%)

SR vs.SD: 2.7 [0.7–10.9] p = 0.1518

 NA

46 (37%)

10 (20%)

36 (51%)

9 (29%)

27 (67,5%)

SD vs.PSS: 4.9 [0.2–101.7] p = 0.3095

Baseline characteristics:

 Creatinine [mg/dl]

n = 111

n = 43

n = 68

n = 31

n = 37

 

0.0095**

 

0.45 ± 0.17

0.51 ± 0.16

0.41 ± 0.17

0.44 ± 0.15

0.39 ± 0.19

SR vs.SS: p = 0.0218*

       

SR vs.PSS: p = 0.0131*

       

SR vs.SD: p = 0.3573

       

SD vs.PSS: p = 0.6836

 Urea [mg/dl]

n = 110

n = 42

n = 68

n = 31

n = 37

  
 

30.7 ± 16.8

33.2 ± 18.1

29.2 ± 18.8

30.3 ± 15.2

28.2 ± 16.5

0.4318

 Uric acid [mg/dl]

n = 100

n = 41

n = 59

n = 25

n = 34

  
 

4.8 ± 1.4

4.9 ± 1.6

4.8 ± 1.3

5 ± 1.5

4.6 ± 1.2

0.7795

 Cystatin C [mg/l]

n = 66

n = 24

n = 42

n = 15

n = 27

  
 

1 (0.3)

1.1 (0.4)

0.9 (0.3)

1.0 (0.3)

0.9 (0.3)

0.0631

 eGFR [ml/min/1,73m3]

n = 111

n = 44

n = 67

n = 29

n = 38

 

0.0009***

 

116.5 ± 46.6

101.3 ± 26.5

126.5 ± 54

116.4 ± 62.5

134.2 ± 45.7

SR vs.SS: p = 0.0141*

       

SR vs.PSS: p = 0.0014**

       

SR vs.SD: p = 0.5236

       

SD vs.PSS: p = 0.0141*

  1. Demographic data was analyzed by the t-student test and the laboratory data was analyzed using ANOVA with Holm adjustment (when data was normally distributed) and Dunn method with Benjamini–Hochberg adjustment and false discovery rate procedure (when data was not normally distributed). Post-hoc analysis was evaluated when global p-value reached significance, i.e. p ≤ 0.05 and significant results are shown in bold; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001
  2. NS, nephrotic syndrome; SR, steroid resistant; SS, steroid sensitive; SD, steroid dependent; PSS, primarily steroid sensitive; MCD, minimal change disease; MPGN, mesangial proliferative glomerulonephritis; FSGS, focal segmental glomerulosclerosis; AOO, age of onset; NA, not available, due to the biopsy not proceeded