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Table 2 Taxonomic identification at the phylum and genus levels in COPD

From: Association of exacerbation phenotype with the sputum microbiome in chronic obstructive pulmonary disease patients during the clinically stable state

Phylum

LRE

HRE

p value

PFT I

PFT II

p value

Patients

60

18

 

43

35

 

Firmicutes

54.59 (41.54–73.32)

43.50 (31.63–60.68)

0.075

48.32 (40–66.09)

57.67 (38.70–69.2)

0.605

Actinobacteria

16.63 (8.48–28.24)

16.71 (11.58–22.79)

0.652

17.08 (8.62–27.99)

15.19 (10.11–24.00)

0.591

Proteobacteria

10.87 (1.69–22.06)

22.28 (8.70–37.70)

0.031

12.66 (1.90–21.82)

11.25 (5.96–24.55)

0.289

Bacteroidetes

3.26 (0.87–6.47)

3.98 (0.27–12.59)

0.610

3.51 (1.22–7.41)

3.18 (0.58–7.55)

0.706

Fusobacteria

2.00 (0.88–4.57)

2.95 (0.57–4.73)

0.585

2.36 (1.04–4.95)

1.65 (0.84–3.44)

0.083

Genera

 Streptococcus

41.24 (28.72–60.15)

28.68 (22.91–35.54)

0.007

39.94 (28.61–60.65)

34.83 (25.70–49.55)

0.226

 Rothia

10.83 (4.31–18.67)

10.20 (4.82–21.14)

0.859

10.86 (4.50–19.53)

10.51 (3.96–16.65)

0.543

 Neisseria

3.07 (0.34–10.51)

3.42 (0.82–11.06)

0.400

3.04 (0.39–9.95)

4.21 (0.31–13.13)

0.393

 Haemophilus

2.72 (0.19–6.43)

1.34 (0.22–11.76)

0.962

3.21 (0.23–6.41)

2.38 (0.16–11.69)

0.868

 Granulicatella

2.54 (1.57–3.93)

2.95 (1.71–5.54)

0.343

2.54 (1.33–3.64)

2.86 (1.77–4.39)

0.317

 Veillonella

1.45 (0.73–3.19)

2.25 (0.69–5.25)

0.226

1.73 (0.71–4.11)

1.64 (0.89–3.48)

0.956

 Leptotrichia

1.30 (0.42–2.67)

1.14 (0.32–3.62)

0.840

1.67 (0.49–3.51)

0.96 (0.36–2.60)

0.353

 Porphyromonas

0.96 (0.03–3.29)

0.94 (0.04–4.50)

0.677

1.03 (0.05–3.39)

0.78 (0.02–3.02)

0.790

 Actinomyces

0.55 (0.19–1.35)

0.92 (0.34–1.48)

0.215

0.82 (0.19–1.43)

0.50 (0.25–1.26)

0.802

 Capnocytophaga

0.37 (0.06–1.58)

0.61 (0.08–1.88)

0.585

0.46 (0.09–1.73)

0.42 (0.04–1.19)

0.457

  1. Data are presented as median (25–75 percentile)
  2. LRE low risk exacerbator, HRE high risk exacerbator, PFT pulmonary function test, PFT I FEV1 ≥ 50, PFT II FEV1 < 50.0
  3. The p value is analyzed using Mann Whitney Wilcoxon test. Bonferroni-adjusted p-values < 0.05/15 (5 phylum and 10 genus) = 0.0033 indicate significance