Fig. 6From: Association of exacerbation phenotype with the sputum microbiome in chronic obstructive pulmonary disease patients during the clinically stable stateDifferentially enriched functions in COPD patients by PICRUSt analysis. Comparison of the relative abundance of the PICRUSt-generated functional profile of the sputum microbiome in COPD patients. Upregulated KEGG pathways associated with HRE subjects are plotted as a heatmap (a) and bar graph (b). Bonferroni-adjusted p-values < 0.05/7 = 0.0071 indicate significance. Upregulated KEGG pathways associated with LRE subjects are plotted as a heatmap (c) and bar graph (d). Bonferroni-adjusted p-values < 0.05/11 = 0.0045 indicate significance. GOLD A, B, C, and D were identified via the GOLD 2017 classification. LRE low-risk exacerbator, HRE high-risk exacerbatorBack to article page