Fig. 4

Pathway enrichment analysis of TMEM119. a, b Pathway associated with TMEM119 in GSEA analyses based on the transcriptomic data of OV patients from the TCGA database (only pathway with NOM p-value < 0.001 and FDR q-value < 0.001 was shown) and the transcriptomic data of 44 ovarian cancer cell lines from the CCLE project (only pathway with NOM p-value < 0.01 was shown) c–d KEGG_FOCAL_ADHESION pathway in GSEA analyses based on the transcriptomic data of OV patients from the TCGA database and the transcriptomic data of 44 ovarian cancer cell lines from the CCLE project. e Venn diagram for the screening of the core enrichment genes in KEGG_FOCAL_ADHESION pathway in both GSEA analyses. f Correlation analyses between the mRNA expression level of TMEM119 and that of PDGFRB in GEPIA database. g–h mRNA and protein expression levels of TMEM119 and PDGFRB in ovarian cancer cells after knockdown of TMEM119 or PDGFRB