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Table 2 Intradialytic changes of plasma concentrations of arginine, guanidinoacetate, creatine and creatinine

From: Creatine homeostasis and protein energy wasting in hemodialysis patients

Metabolite

Total cohort

Males

Females

P-value

Arginine

 Predialysis concentration, μmol/L

77 ± 22***

80 ± 24***

72 ± 18***

0.2

 Postdialysis concentration, μmol/L

60 ± 19***

63 ± 21***

55 ± 14***

0.08

 Absolute decrease, μmol/L

17 ± 23***

17 ± 25***

16 ± 19***

0.9

 Proportional decrease, %

18 ± 25***

17 ± 28***

20 ± 21***

0.7

Guanidinoacetate

 Predialysis concentration, μmol/L

1.8 ± 0.6***

1.9 ± 0.6***

1.6 ± 0.5

0.1

 Postdialysis concentration, μmol/L

1.0 ± 0.3***

1.1 ± 0.3***

0.9 ± 0.4

0.07

 Absolute decrease, μmol/L

0.8 ± 0.4***

0.8 ± 0.5***

0.7 ± 0.4***

0.4

 Proportional decrease, %

40 ± 17***

38 ± 17***

43 ± 15***

0.3

Creatine

 Predialysis concentration, μmol/L

26 [16–41] ***

19 [15–33] *

33 [24–56] ***

0.01

 Postdialysis concentration, μmol/L

21 [15–30] ***

20 [15–25] *

24 [15–37] ***

0.01

 Absolute decrease, μmol/L

5 [1–14] ***

3 [0–8] *

10 [3–18] ***

0.02

 Proportional decrease, %

13 ± 39*

5 ± 43

27 ± 26***

0.02

Creatinine

 Predialysis concentration, μmol/L

689 ± 207***

706 ± 224***

660 ± 175***

0.4

 Postdialysis concentration, μmol/L

257 ± 92***

274 ± 97***

228 ± 78***

0.07

 Absolute decrease, μmol/L

432 ± 146***

432 ± 156***

432 ± 130***

0.9

 Proportional decrease, %

63 ± 8***

61 ± 9***

65 ± 7***

0.05

  1. Differences between males and females are tested using an independent sample t-test. Differences between predialysis and postdialysis plasma concentrations are tested using paired sample t-test or the paired samples Wilcoxon test. Absolute decrease and proportional decrease are test against no decrease by t-test or Wilcoxon test. Statistical significance is indicated with asterixis (* P < 0.05; ** P < 0.01; *** P < 0.001)