Fig. 2
From: MBTPS2, a membrane bound protease, underlying several distinct skin and bone disorders
adapted from Feng et al. [65]. d Amino sequence alignments of human S2P and MjS2P at the catalytic active motifs. Sequences were obtained from NCBI Protein Database, aligned using Clustal Omega Software [126], and cropped at the catalytic active motifs (green letters). An asterisk (*) indicates positions which have a single, fully conserved residue. A: (colon) indicates conservation between alignments of strongly similar properties. A. (period) indicates conservation between alignments of weakly similar properties
Organization of the MBTPS2 gene and the S2P protein structure. a Structure of human MBTPS2 gene consists of 11 exons and is located on human chromosome X. b Predicted structure of human S2P protein contains eight transmembrane domains, a polyserine tract, a PDZ domain, and catalytic active motifs, HEIGH and LDG. c Membrane topology of MjS2P,