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Table 3 Performance of urinary KIM-1 for AKI diagnosis in studies included in the meta-analysis

From: The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis

Study_year TP FN FP TN Assay method Timing of measurement KIM-1 cutoff Sensitivity (95% CI) Specificity (95% CI) AUC (95% CI)
Khreba_2019 13 14 1 17 ELISA 3 h after operation 1.9 ng/mg 0.48 (NR) 0.94 (NR) 0.715 (NR)
Wybraniec_2017 7 2 15 71 ELISA 6 h after CA 0.43 ng/mg 0.778 (NR) 0.824 (NR) 0.81 (NR)
Sinkala_2016 6 7 9 18 ELISA NR 3.1 ng/ml 0.441 (NR) 0.67.6 (NR) 0.35 (0.226–0.474)
van Wolfswinkel_2016 6 0 9 24 ELISA On admission 1.83 ng/ml 1 (0.54–1.00) 0.52 (0.54–0.87) 0.87 (0.75–0.99)
Torregrosa_2014 14 6 45 79 ELISA 12 h after surgery 1.73 ng/ml 0.716 (NR) 0.64 (NR) 0.713 (0.551–0.876)
Tekce_2014 7 1 1 13 ELISA On first day after treatment 1.412 ng/ml 0.875 (NR) 0.933 (NR) 0.94 (0.75–0.99)
Nickolas_2012 50 46 323 1216 chemiluminescent microparticle immunoassay Within 12 h after patient enrollment 2.817 ng/ml 0.52 (NR) 0.79 (NR) 0.71 (0.65–0.76)
Naggar_2012 18 2 1 19 ELISA Within 1 day after patient enrollment NR 0.909 (NR) 0.952 (NR) NR (NR)
Endre_2011 102 154 52 220 microsphere-based Luminex xMAP technology NR 1.86 ng/mg 0.40 (0.32–0.48) 0.81 (0.77–0.85) 0.66 (0.61–0.72)
Liang_2010 27 3 20 72 ELISA 12 h after surgery 2.0 ng/mg 0.90 (NR) 0.788 (NR) 0.882 (0.812–0.934)
Ferguson_2010 71 21 0 42 ELISA NR 1.7 ng/mg 0.77 (0.67–0.85) 1 (0.92–1.0) 0.89 (0.82–0.94)
Liangos_2009 12 1 38 52 ELISA 2 h after surgery 0.42 ng/mg 0.92 (NR) 0.58 (NR) 0.78 (0.64–0.91)
Han_2009 19 17 12 42 ELISA Post-operation Immediately 1.2 ng/mg 0.5143 (NR) 0.7778 (NR) 0.68 (0.58–0.78)
Vaidya_2008 92 10 4 98 ELISA The time of initial consultation 0.70 ng/mg 0.90 (NR) 0.96 (NR) 0.95 (0.90–0.98)
  1. KIM-1 kidney injury molecule 1, AUC area under curve, CI confidence interval, TP true positive, FN false negative, FP false positive, TN true negative, ELISA enzyme-linked immunosorbent assay, CA coronary angiography, NR not reported