Fig. 5

a Inner ring: scatter plot of mean methylation difference (shown as delta beta value) versus expression difference (shown as log Fold change) in 7 cancer types. Each point represents a CpG-gene pair. Outer ring: Bar plot exhibited the distribution of differentially methylated and expressed genes across gene regions (promoter only: TSS1500, TSS200, 5′-UTR, 1st exons) in different cancer types. b Invasiveness-associated copy number variations (CNVs) across twelve cancer types. The results show significantly higher CNV frequency in high-invasiveness score group (red), and lower frequency in low-invasiveness score group (blue). c Common upregulated miRNAs and downregulated genes in high-invasiveness score group across multiple cancer types. The arc plot (right) shows the targeting relationship (thin lines) between miRNAs (green dots) and genes (purple dots). The heatmaps (left) exhibits the log Fold change (high-invasiveness vs. low-invasiveness) of each miRNA and gene in different cancer types, where red cell represents significantly upregulated while blue represents significantly downregulated and white represents no-significance