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Table 3 Association of BRCA1/BRCA2 carriers with tumor site and triple negative status in patients divided according to the age at diagnosis

From: Novel and recurrent BRCA1/BRCA2 germline mutations in patients with breast/ovarian cancer: a series from the south of Tunisia

Age Tumor Site Non carriers (%) BRCA1 carriers (%) BRCA2 carriers (%) p
≤ 30 BC 7 (77.8) 1 (11.1) 1 (11.1)
OC 0 (0) 0 (0) 0 (0)  
31–40 BC 44 (86.3) 4(7.8) 3 (5.9) 0.001
OC 1 (25) 3 (75) 0 (0)  
41–50 BC 22 (91.7) 0 (0) 2 (8.3) 0.044
OC 7 (77.8) 2 (22.2) 0 (0)  
≥ 51 BC 23 (88.5) 0 (0) 3 (11.5) 0.24
OC 11 (100) 0 (0) 0 (0)  
Age TN Non carriers (%) BRCA1 carriers (%) BRCA2 carriers (%) p
≤ 30 No 4 (100) 0 (0) 0 (0) 0.358
Yes 3 (60) 1 (20) 1 (20)  
31–40 No 34 (89.5) 1 (2.6) 3 (7.9) 0.041
Yes 10 (76.9) 3 (23.1) 0 (0)  
41–50 No 17 (89.5) 0 (0) 2 (10.5) 0.449
Yes 5 (100) 0(0) 0 (0)  
≥ 51 No 20(87) 0 (0) 3 (13) 0.506
Yes 3 (100) 0 (0) 0 (0)  
  1. BC: Breast cancer; OC: ovarian cancer (with or without breast cancer); Yes: TN (ER−/PR−/Her2−); No: others (ER−/PR−/Her2+, ER+/PR+/Her2+, ER+/PR+/Her2−)