Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

Table 1 Correlation between gene expression and methylation of CRC in TCGA database

Gene	Methylation			Expression			Correlation
Gene	Normal	Tumor	P	Normal	Tumor	P	Cor	P
KHDRBS2	0.156 ± 0.031	0.443 ± 0.091	< 0.001	4.678 ± 0.981	0.753 ± 1.007	< 0.001	− 0.594	< 0.001
GPM6A	0.308 ± 0.150	0.325 ± 0.053	< 0.001	7.837 ± 1.658	3.036 ± 2.459	< 0.001	0.018	0.708
HPSE2	0.259 ± 0.022	0.363 ± 0.053	< 0.001	7.536 ± 0.506	3.660 ± 1.555	< 0.001	− 0.351	< 0.001
KCNA1	0.316 ± 0.027	0.557 ± 0.104	0.131	3.389 ± 1.915	1.096 ± 1.367	< 0.001	− 0.383	< 0.001
PHOX2A	0.270 ± 0.038	0.451 ± 0.075	< 0.001	4.470 ± 1.039	1.090 ± 1.259	< 0.001	− 0.411	< 0.001
RSPO2	0.283 ± 0.034	0.450 ± 0.075	< 0.001	7.715 ± 0.906	2.982 ± 1.805	< 0.001	− 0.455	< 0.001
RXRG	0.242 ± 0.137	0.461 ± 0.116	< 0.001	6.019 ± 0.590	1.920 ± 1.284	< 0.001	− 0.404	< 0.001
GFRA1	0.393 ± 0.017	0.571 ± 0.079	< 0.001	9.050 ± 0.826	5.791 ± 1.885	< 0.001	− 0.357	< 0.001
TMEFF2	0.324 ± 0.022	0.517 ± 0.089	< 0.001	5.336 ± 0.848	1.260 ± 1.291	< 0.001	− 0.431	< 0.001
LRRC3B	0.577 ± 0.026	0.534 ± 0.081	0.016	3.120 ± 0.969	0.667 ± 0.874	< 0.001	0.138	0.004
NOVA1	0.175 ± 0.130	0.359 ± 0.118	< 0.001	0.232 ± 0.016	0.437 ± 0.127	< 0.001	− 0.492	< 0.001
ADCYAP1R1	0.431 ± 0.010	0.359 ± 0.059	< 0.001	6.537 ± 1.170	2.442 ± 1.826	< 0.001	0.246	< 0.001
PRIMA1	0.301 ± 0.015	0.390 ± 0.093	< 0.001	9.030 ± 1.064	3.451 ± 2.171	< 0.001	− 0.222	< 0.001
EPHA7	0.121 ± 0.009	0.340 ± 0.155	< 0.001	8.333 ± 1.425	4.669 ± 1.993	< 0.001	− 0.431	< 0.001

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