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Table 1 Correlation between gene expression and methylation of CRC in TCGA database

From: Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

Gene Methylation Expression Correlation
Normal Tumor P Normal Tumor P Cor P
KHDRBS2 0.156 ± 0.031 0.443 ± 0.091  < 0.001 4.678 ± 0.981 0.753 ± 1.007  < 0.001  − 0.594  < 0.001
GPM6A 0.308 ± 0.150 0.325 ± 0.053  < 0.001 7.837 ± 1.658 3.036 ± 2.459  < 0.001 0.018 0.708
HPSE2 0.259 ± 0.022 0.363 ± 0.053  < 0.001 7.536 ± 0.506 3.660 ± 1.555  < 0.001  − 0.351  < 0.001
KCNA1 0.316 ± 0.027 0.557 ± 0.104 0.131 3.389 ± 1.915 1.096 ± 1.367  < 0.001  − 0.383  < 0.001
PHOX2A 0.270 ± 0.038 0.451 ± 0.075  < 0.001 4.470 ± 1.039 1.090 ± 1.259  < 0.001  − 0.411  < 0.001
RSPO2 0.283 ± 0.034 0.450 ± 0.075  < 0.001 7.715 ± 0.906 2.982 ± 1.805  < 0.001  − 0.455  < 0.001
RXRG 0.242 ± 0.137 0.461 ± 0.116  < 0.001 6.019 ± 0.590 1.920 ± 1.284  < 0.001  − 0.404  < 0.001
GFRA1 0.393 ± 0.017 0.571 ± 0.079  < 0.001 9.050 ± 0.826 5.791 ± 1.885  < 0.001  − 0.357  < 0.001
TMEFF2 0.324 ± 0.022 0.517 ± 0.089  < 0.001 5.336 ± 0.848 1.260 ± 1.291  < 0.001  − 0.431  < 0.001
LRRC3B 0.577 ± 0.026 0.534 ± 0.081 0.016 3.120 ± 0.969 0.667 ± 0.874  < 0.001 0.138 0.004
NOVA1 0.175 ± 0.130 0.359 ± 0.118  < 0.001 0.232 ± 0.016 0.437 ± 0.127  < 0.001  − 0.492  < 0.001
ADCYAP1R1 0.431 ± 0.010 0.359 ± 0.059  < 0.001 6.537 ± 1.170 2.442 ± 1.826  < 0.001 0.246  < 0.001
PRIMA1 0.301 ± 0.015 0.390 ± 0.093  < 0.001 9.030 ± 1.064 3.451 ± 2.171  < 0.001  − 0.222  < 0.001
EPHA7 0.121 ± 0.009 0.340 ± 0.155  < 0.001 8.333 ± 1.425 4.669 ± 1.993  < 0.001  − 0.431  < 0.001