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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

Fig. 7

HPSE2 performs a tumor suppressive function by activating the p53/ p21 signaling cascade. a HPSE2 mRNA expression in 5 CRC cell lines and 1 intestinal epithelial cell; b HPSE2 overexpression in SW480 and HCT116 was confirmed through qRT-PCR; c, d HPSE2 overexpression significantly inhibited SW480 (c) and HCT116 (d) proliferation; e, f HPSE2 overexpression inhibited SW480 (e) and HCT116 (f) migration; g HPSE2 blocked the SW480 and HCT116 cell cycle in the G1–S stage; h, i Images of tumor specimens; j HPSE2 overexpression significantly suppressed tumorigenicity in vivo; k Immunohistochemistry results for mouse tumor tissues: ki67 expression was decreased in the HPSE2-overexperssing and control group; l GSEA plot showed pathways that were significantly related to HPSE2 (p < 0.05); m Western blot analysis showed that HPSE2 overexpression could upregulate p53/p21 levels in HCT116 and SW480. *P < 0.05, **P < 0.01, ***P < 0.001

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