Fig. 3

HPSE2, which was regulated by promoter DNA methylation, could be an independent prognostic factor. a Methylation levels of HPSE2 in 22 cases of CRC tissues in GSE17648; b Methylation levels of HPSE2 in 26 cases of matched CRC tumors and adjacent normal tissues in GSE29490; HPSE2 expression (c) and methylation (d) in TCGA database; e, f Kaplan–Meier curves showing that hypermethylation–low expression of HPSE2 was associated with the shortened survival of CRC patients at the late stages (f) but not at the early stages (e); g Univariate and multivariate COX regression model revealed that HPSE2 could be an independent prognostic risk factor. ***P < 0.001