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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Lipoprotein glomerulopathy induced by ApoE Kyoto mutation in ApoE-deficient mice

Fig. 6

Oil-red O-positive staining and atherosclerosis plaque area in the aortic valve in the five groups. The atherosclerosis plaque with Oil-red O-positive staining in the aortic valve was observed in 3-month old ApoE (−/−) mice with chow diet and was shown in (f) as baseline group. Three month later, atherosclerosis plaque area of five groups were increased and shown in (a) ApoE (−/−), (b) AD-eGFP, (c) AD-ApoE Sendai, (d) AD-ApoE Kyoto, (e) AD-ApoE3. The atherosclerotic plaque area and its percentage in area difference of aorta adventitia and intima in the aortic valve were quantified by the Motic images Advanced 3.2 software, the (g and h) atherosclerosis plaque area and (i and j) percentage of aortic valve level are shown. In Panel (h and j), the AD-ApoE Sendai, AD-ApoE Kyoto, and AD-ApoE3 groups were pooled as human apoE injection group while the ApoE (−/−) and AD-eGFP groups were pooled as non-APOE injection group

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