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Table 2 Logistic regression analysis for prognostic factors of long-term (≧17 courses) response of pemetrexed

From: High lymphocyte population-related predictive factors for a long-term response in non-small cell lung cancer patients treated with pemetrexed: a retrospective observational study

Characteristics

Univariate analysis

Multivariate analysis

P value

Hazard ratio

(95%CI)

P value

Hazard ratio

(95%CI)

Age

0.006*

1.067 (1.018–1.118)

0.027*

1.068 (1.007–1.132)

Sex

0.588

0.797 (0.351–1.810)

0.125

0.413 (0.133–1.279)

ECOG PS

0.228

3.485 (0.457–26.580)

0.459

0.441 (0.051–3.851)

Smoking history

0.425

0.691 (0.279–1.713)

0.261

0.492 (0.143–1.694)

Stage (8th edition)

0.013*

0.656 (0.470–0.914)

0.030*

0.666 (0.461–0.962)

Therapy line

0.630

1.232 (0.526–2.887)

0.876

0.918 (0.313–2.690)

Platinum combination

0.463

1.378 (0.585–3.247)

0.764

0.841 (0.272–2.604)

Neutrophils (/mm2)

0.228

1.000 (1.000–1.000)

0.041*

1.000 (0.999–1.000)

Lymphocytes (/mm2)

0.020*

1.000 (1.000–1.001)

0.033*

1.001 (1.000–1.001)

Monocytes (/mm2)

0.337

1.001 (0.999–1.003)

0.016*

1.001 (1.001–1.007)

NLR

0.023*

0.693 (0.505–0.951)

※

※

  1. ALC absolute lymphocyte count (/mm3), ECOG PS Eastern Cooperative Oncology Group Performance Status, NLR Neutrophil-to-Lymphocyte ratio, 95%CI 95% confidence interval
  2. *: P < 0.05 (Binomial logistic regression)
  3. ※: Not available due to multi-collinearity