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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3

Fig. 1

Niclosamide ameliorates disease aggravation in MRL/lpr mice. Female 10-week-old MRL/lpr mice were orally administered 0.5% methyl cellulose (vehicle, n = 7), or 100 mg/kg niclosamide (Niclosamide, n = 7) daily until they were 16-week-old. a Left, Representative photographs documenting the enlargement of kidneys. Right, kidney weights in vehicle, niclosamide groups. b Urine albumin levels normalized to creatinine. c Serum levels of anti-dsDNA IgG antibody. d Serum levels of antibody subclasses (IgG, IgG1, and IgM). e Serum levels of IL-6 and IL-21. f Left, representative photomicrographs of PAS-stained sections of kidney. Original magnification ×200 (upper), ×100 (middle, bottom). Right, histological score. g Left, representative immunofluorescent images of kidney C3 staining. Original magnification ×100 (upper), ×400 (bottom). Right, MFI of C3 deposition. Data shown as mean ± SD. t-test was performed. *P < 0.05, **P < 0.01, ***P < 0.001

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