Fig. 7

Binding affinity to the H2-Db molecule. Binding to H2-Db molecule was assessed in TAP-deficient RMA-S murine cells loaded with the indicated peptides. a Mean fluorescence intensity at flow cytometer indicates binding levels of HPV-E7 wt and heteroclitic peptides to the H2-Db molecule at the different concentrations. b Fold-increase (wt = 1) of the binding to the H2-Db molecule of each heteroclitic peptides at the different concentrations. c Mean fluorescence intensity at flow cytometer indicates binding levels of wt and heteroclitic Trp2 peptides to the H2-Db molecule at the different concentrations. d Fold-increase (wt = 1) of the binding to the H2-Db molecule of each heteroclitic peptides at the different concentrations