Fig. 4

Predicted peptide conformation. a, b The conformation of the wt HPV-E7 and Trp2 peptides, bound to the H2-Db molecule, is shown compared to the LCMV peptide KAVYNFATC (1FG2, protein data bank). The amino acid at the anchor position 5 is highlighted for the three peptides. The presence of the non-polar Phenylalanine (Phe, F) in the Trp2 peptide results in a very poor binding to the H2-Db molecule, compared to the HPV-E7 and LCMV peptides