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Table 2 Lead SNPs Associated with CVD at Genome-wide Significance by GWAS

From: Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia

 

SNP

Position

Locus

Clustered SNPs

M/m

MAF

1000GenomeFreq

Frequency

Genes

Feature

CAD

IS

CCD

Asian

Eur

Amer

OR

P

OR

P

OR

P

HTN

rs1550676

17:77,801,055

17q25.3

rs74608211, rs145216691, rs559385953

T/C

0.01176

–

–

–

CBX8-CBX4,

CBX2

GAA

CARD14

SLC26A11

Intergenic

2.607 (1.886–3.602)

6.37E−09

0.5929 (0.2625–1.339)

2.09E−01

1.927 (1.417–2.621)

2.90E−05

DM

rs149608518

4:165,472,675

4q32.3

–

C/T

0.01035

0.0079

0

0

MARCH1-LINC01207,

APELA

Intergenic

1.425 (0.7313–2.775)

2.98E−01

5.587 (3.086–10.12)

1.34E−08

2.68 (1.639–4.384)

8.55E−05

rs139293840

17:78,530,359

17q25.3

rs957271283, rs147509862

G/A

0.01013

0.0089

0.001

0

RPTOR,

RNF213

CARD14

SLC26A11

Intron

3.359 (2.058–5.484)

1.27E−06

3.111 (1.581–6.124)

1.02E−03

3.511 (2.265–5.444)

1.99E−08

DL

rs189668056

2:38,308,827

2p22.2

rs189258819

G/A

0.02031

0.0129

0

0.0187

CYP1B1-

CYP1B1-AS1

Intergenic

1.942 (1.453–2.596)

7.30E−06

2.147 (1.401–3.292)

4.55E−04

2.027 (1.574–2.609)

4.24E−08

rs3897976

3:41,606,692

3p22.1

–

G/A

0.05095

0.0823

0.1074

0.1153

ULK4,

CTNNB1

Intron

1.008 (0.801–1.269)

9.46E−01

2.162 (1.646–2.84)

2.97E−08

1.301 (1.083–1.562)

4.86E−03

rs79166762

9:92,466,006

9q22.2

rs12115796, rs12115684, rs12115802, rs75847266, rs117445944, rs75273685, rs76097735, rs78819980, rs79641632

T/C

0.01918

0.0159

0

0

UNQ6494-

LOC101927847,

GADD45G

SEMA4D

Intergenic

2.282 (1.724–3.019)

7.78E−09

1.207 (0.6891–2.114)

5.11E−01

1.928 (1.483–2.505)

9.17E−07

  1. Lead SNPs were selected within genome-wide significant variants by lowest p-values. Genes include positional candidate genes within 400 kb of SNP, and initial mapped gene or genetic region is listed first before a comma. Odds ratios are shown as odds ratio (95% confidence interval). SNP, single nucleotide polymorphism; M/m, Major/minor allele; MAF, minor allele frequency; OR, odds ratio; P, p-value