| Model1 | Model2 | Model3 | ||||||
---|---|---|---|---|---|---|---|---|---|
Adjusted HR (95% CI) | β | P value | Adjusted HR (95% CI) | β | P value | Adjusted HR (95% CI) | β | P value | |
Females | |||||||||
 Low-increasing | Reference |  |  | Reference |  |  | Reference |  |  |
 High-stable | 2.21 (1.76–2.76) | .79 | 0.000 | 1.68 (1.27–2.21) | .51 | 0.000 | 1.67 (1.26–2.20) | 0.50 | 0.000 |
 High- increasing | 3.28 (2.43–4.45) | 1.19 | 0.000 | 2.50 (1.76–3.50) | .91 | 0.000 | 2.78 (1.79–3.60) | 0. 93 | 0.000 |
Males | |||||||||
 Stable | Reference |  |  | Reference |  |  | Reference |  |  |
 Low–increasing | 2.47 (1.38–4.43) | 0.90 | 0.002 | 2.85 (1.58–5.13) | 1.04 | 0.002 | 2.76 (1.49–5.10) | 1.01 | 0.001 |
 High-increasing | 2.68 (1.46–4.90) | 0.98 | 0.001 | 1.48 (0.76–2.89) | 0.39 | 0.24 | 1.44 (0.74–2.81) | 0.36 | 0.28 |