Table 3 Summary of models predicting high-risk RS (RS > 25) with clinicopathological characteristics
From: A nomogram to predict the high-risk RS in HR+/HER2-breast cancer patients older than 50 years of age
Year | Author | Patients (n) | Predictors | Type of variables | Calibration | Discrimination |
|---|---|---|---|---|---|---|
2016 | Hyun-seok Kim et al | Training n = 1113 | ER | Numerical (percent) | 52.50% | / |
Validation n = 472 | PR | Numerical (percent) | ||||
Ki-67 | Numerical (percent) | |||||
HER2 | Categorical (negative/positive) | |||||
Elston grade | Categorical (Low/Intermediate/High) | |||||
2019 | Amila Orucevic et al | Training n = 65,754 | Age | Numerical | 86.80% | 0.81 |
Validation n = 18,585 | Size | Numerical | ||||
Grade | Categorical (1/2/3) | |||||
PR | Categorical (negative/positive) | |||||
Histology | Categorical (IDC/ILC/IDC + ILC/IDC + others) | |||||
2019 | Sae Byul Lee et al | Training n = 340 | ER Allred score | Numerical (0–8) | / | 0.90 |
Validation n = 145 | PR Allred score | Numerical (0–8) | ||||
Nuclear grade | Categorical (1/2/3) | |||||
LVI | Categorical (negative/positive) | |||||
Ki-67 | Numerical (percent) | |||||
2019 | Shin Hye Yoo et al | Training n = 192 | Nuclear grade | Categorical (Low-Intermediate/High) | / | 0.856 |
Validation n = 264 | PR | Categorical (negative/positive) | ||||
Ki-67 | Numerical (percent) | |||||
The current study | Training n = 1100 1000 bootstrap internal validation, external validation n = 282 | Histologic subtype | Categorical (IDC/mixed/others) | |||
Grade | Categorical (1/2/3) | 0.798 | ||||
ER | Numerical (percent) | |||||
PR | Numerical (percent) | |||||
Ki-67 | Numerical (percent) | |||||