Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

Table 3 Model fit among seven models including or not including NTRK3 methylation status

Models	N	AIC	LR	P value
Model 1	219	597.73	6.91
Model 2	219	600.69	5.95	0.005^a
Model 3	219	592.41	16.23	0.002^b
Model 4	219	516.49	39.06
Model 5	219	513.91	43.64	0.032^c

N: patient counts in each model; AIC: Akaike information criterion value; LR: likelihood ratio
Model 1 includes NTRK3 hypermethylation
Model 2 includes TNM stage (I, II, III)
Model 3 includes TNM stage (I, II, III), NTRK3 hypermethylation
Model 4 includes age at diagnosis, sex (m/f), location(left colon, right colon, rectum), differentiation (well, moderate, poor), lymphovascular invasion, perineural invasion (n/y), T stage (T1, T2, T3, T4), N stage (N0, N1, N2), negative lymph node number, preoperation CEA, chemotherapy(n/y)
Model 5 includes NTRK3 hypermethylation and all variables in Model 4
^aP values for the LR test in model 1 compared with model 2; ^bP values for the LR test in model 2 compared with model 3; ^cP values for the LR test in model 4 compared with model 5

ISSN: 1479-5876