From: Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer
Variables | Total | NTRK3 promotor methylation | P value | |
---|---|---|---|---|
Hypomethylation | Hypermethylation | |||
Age (median = 62 years) | ||||
 < 62 | 111 | 100 | 11 |  |
 ≥ 62 | 118 | 103 | 15 | 0.504 |
Sex | ||||
 Female | 100 | 88 | 12 |  |
 Male | 129 | 115 | 14 | 0.786 |
Tumor localization | ||||
 Colon | 126 | 114 | 12 |  |
 Rectum | 103 | 89 | 14 | 0.334 |
Tumor size (median = 4.5 cm) | ||||
 < 4.5 | 104 | 90 | 14 |  |
 ≥ 4.5 | 123 | 111 | 12 | 0.382 |
 Unknown | 2 |  |  |  |
Tumor differentiation | ||||
 High or moderate | 191 | 168 | 23 |  |
 Poor | 38 | 35 | 3 | 0.584 |
Lymphovascular invasion | ||||
 No | 210 | 188 | 22 |  |
 Yes | 17 | 13 | 4 | 0.219 |
 Unknown | 2 |  |  |  |
Perineural invasion | ||||
 No | 208 | 183 | 25 |  |
 Yes | 19 | 18 | 1 | 0.611 |
 Unknown | 2 |  |  |  |
TNM stage | ||||
 I–II | 143 | 123 | 20 |  |
 III–IV | 85 | 79 | 6 | 0.112 |
 Unknown | 1 |  |  |  |
CIMP | ||||
 Negative | 222 | 198 | 24 |  |
 Positive | 7 | 5 | 2 | 0.145 |
Microsatellite status | ||||
 MSS | 125 | 113 | 12 |  |
 MSI | 51 | 39 | 12 | 0.015 |
 Unknown | 53 |  |  |  |
KRAS | ||||
 Wild-type | 119 | 110 | 9 |  |
 Mutation | 62 | 46 | 16 | 0.001 |
 Unknown | 48 |  |  |  |
BRAF | ||||
 Wild-type | 174 | 151 | 23 |  |
 Mutation | 8 | 6 | 2 | 0.674 |
 Unknown | 47 |  |  |  |
Ki-67 | ||||
 ≤ 25% | 100 | 89 | 11 |  |
 > 25% | 84 | 72 | 12 | 0.502 |
 Unknown | 45 |  |  |  |
CA19-9 | ||||
 ≤ 37 | 179 | 160 | 19 |  |
 > 37 | 32 | 29 | 3 | 0.833 |
 Unknown | 18 |  |  |  |
CEA | ||||
 ≤ 5 | 158 | 138 | 20 |  |
 > 5 | 57 | 54 | 3 | 0.122 |
 Unknown | 14 |  |  |  |