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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

Fig. 3

Prognostic significance of NTRK3 promoter methylation. a, b Kaplan–Meier curves of disease-free survival according to NTRK3 promoter methylation in CRC. Kaplan–Meier curves for the whole validation cohort (a) and stage I-III subgroup (b) were shown. The P value for each log-rank test was presented in the plots. Number at risk showed the quantity of CRC patients with NTRK3 hyper- or hypo- methylation and among them the quantity of survivors or dead patients respectively. c, d A nomogram and calibration curve for predicting DFS in CRC. A nomogram to predict individual patient-level 3-year, and 5-year DFS based on clinicopathological risk factors and NTRK3 methylation (c). Calibration plots for the validation sample of the above nomogram (d). Actual DFS statue measured via Kaplan–Meier analysis is shown on the Y-axis, and the nomogram-predicted probability of DFS statue is shown on the X-axis. The average nomogram-predicted probability of DFS was plotted against actually observed DFS estimated by Kaplan–Meier. 95% confidence intervals of the Kaplan–Meier estimates are indicated with vertical lines. Grayline indicates the reference line, showing where an ideal nomogram would lie. Instructions for users: Locate the status on each variable axis, and draw a straight line up to the Points axis to determine how many points toward risk the patient should receive from each variable. Sum the points and locate this number on the Total Points axis. Draw a straight line down from the total points to the 3-year or 5-year DFS Probability axis to ascertain the patient’s specific possibility of maintaining DFS until 3 or 5 years. e, f Pan-cancer analysis of the prognostic significance of NTRK3 promoter methylation. The forest plots showed the values of the HR and CI for the prediction of the survival outcomes in univariate Cox analysis for the methylation of cg27034819 (e) and cg11525479 (f) in 23 TCGA cancer types. The x-axes presenting HRs were log2-scaled

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