Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Table 4 Multivariate Cox PH model testing the association of nominated variables with melanoma OS

Covariate	N	HR (95% CI)	P
Age at primary diagnosis*	278 (100.0%)	1.02 (1.01–1.04)	7.06E−04
Stage at primary diagnosis
Local	137 (49.3%)	Ref
Regional/advanced	141 (50.7%)	1.69 (1.15–2.47)	7.19E−03
TMB
High	220 (79.1%)	Ref
Low	58 (20.9%)	2.56 (1.67–3.92)	1.57E−05
MacReg*	278 (100.0%)	0.75 (0.56–1.00)	4.76E−02
IFNγRes*	278 (100.0%)	0.80 (0.63–1.02)	7.16E−02
Log-rank test: P = 8.80E−14

Nominated variables included low TMB (defined as ≤ 125 mutations), age at diagnosis*, MacReg*, IFNγRes*, and stage at diagnosis (local (stage I/II), regional/advanced (stage III/IV)). Hazard ratios and 95% confidence intervals (HR 95% CI) and p-values (P) for each variable are reported. The overall model goodness of fit as determined by the log-rank test is 8.80E−14
^*Was used as a continuous variable in Multivariate Cox proportional hazard model

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