Skip to main content

Table 4 Multivariate Cox PH model testing the association of nominated variables with melanoma OS

From: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Covariate N HR (95% CI) P
Age at primary diagnosis* 278 (100.0%) 1.02 (1.01–1.04) 7.06E−04
Stage at primary diagnosis
 Local 137 (49.3%) Ref  
 Regional/advanced 141 (50.7%) 1.69 (1.15–2.47) 7.19E−03
TMB
 High 220 (79.1%) Ref  
 Low 58 (20.9%) 2.56 (1.67–3.92) 1.57E−05
MacReg* 278 (100.0%) 0.75 (0.56–1.00) 4.76E−02
IFNγRes* 278 (100.0%) 0.80 (0.63–1.02) 7.16E−02
Log-rank test: P = 8.80E−14    
  1. Nominated variables included low TMB (defined as ≤ 125 mutations), age at diagnosis*, MacReg*, IFNγRes*, and stage at diagnosis (local (stage I/II), regional/advanced (stage III/IV)). Hazard ratios and 95% confidence intervals (HR 95% CI) and p-values (P) for each variable are reported. The overall model goodness of fit as determined by the log-rank test is 8.80E−14
  2. *Was used as a continuous variable in Multivariate Cox proportional hazard model