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Table 3 The 10 most significant multivariate Cox PH models as measured by log-rank p-value

From: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Model (adjusted by age and stage at primary diagnosis) Discovery (N = 139)
Validation 2 (N = 69)
Pooled (Discovery + Validation 2, N = 208)
Meta (N = 278)
TMB + MacReg + IFNγRes 1.70E−07 1.28E−02 3.37E−10 8.80E−14
TMB + IFNγRes 1.71E−07 1.74E−02 8.26E−10 2.09E−13
MacReg * IFNγRes + TMB 2.16E−07 1.03E−02 1.12E−09 3.30E−13
TMB + Lymphocyte infiltration signature score + IFNγRes 2.84E−07 1.44E−02 6.87E−10 2.88E−13
TMB + MacReg 2.90E−07 6.66E−03 5.23E−10 2.64E−13
Lymphocyte infiltration signature score * IFNγRes + TMB 3.24E−07 2.51E−02 1.97E−09 1.10E−12
TMB * MacReg + IFNγRes 3.40E−07 2.26E−03 6.04E−10 9.59E−14
TMB * IFNγRes + MacReg 3.53E−07 2.22E−02 1.18E−09 3.46E−13
Lymphocyte infiltration signature score * IFNγRes + TMB + MacReg 4.07E−07 3.80E−02 3.05E−09 1.02E−12
TMB * IFNγRes 4.84E−07 3.16E−02 3.04E−09 9.12E−13
  1. Models were adjusted by age and stage at primary diagnosis with covariates that were associated with survival in univariate Cox PH regressions. Interaction effects between variables were assessed (*). The model that was most significantly associated with survival included MacReg, IFNγRes, and TMB. The full table of results are provided in Additional file 1: Table S5