Skip to main content

Table 2 The results of univariate Cox PH ratio analysis testing the association of 53 immunogenomic covariates with OS in discovery, validation 1, and pooled cohorts

From: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Variable

Discovery (N = 139)

Validation 1 (N = 70)

Pooled (Discovery + validation 1) (N = 209)

ß

HR (95% CI)

P

ß

HR (95% CI)

P

ß

HR (95% CI)

P

TMB (low)

1.26

3.52 (2.00–6.20)

1.30E–05

1.05

2.86 (1.23–6.62)

0.01

1.21

3.36 (2.10–5.36)

4.01E–07

IFNγRes

0.46

0.63 (0.48–0.84)

1.43E–03

– 0.76

0.47 (0.27–0.82)

8.00E–03

 − 0.50

0.60 (0.48–0.77)

4.99E–05

MacReg

0.48

0.62 (0.43–0.88)

8.18E–03

– 0.59

0.56 (0.35–0.89)

0.02

 − 0.50

0.61 (0.46–0.80)

3.87E–04

Tumor infiltration (regional) fraction

0.05

0.95 (0.91–0.99)

0.02

– 0.04

0.96 (0.90–1.02)

0.19

 − 0.05

0.96 (0.92–0.99)

8.00E–03

Lymphocyte infiltration signature score

0.22

0.80 (0.67–0.97)

2.29E–02

– 0.25

0.78 (0.62–0.99)

0.04

 − 0.22

0.80 (0.70–0.93)

2.40E–03

Number of CNV segments

0.00

1.00 (1.00–1.00)

0.02

3.00E–03

1.00 (1.00–1.01)

0.07

1.74E–03

1.00 (1.00–1.00)

4.00E–03

Activated mast cells

0.22

1.24 (1.01–1.53)

0.04

17.38

3.55E + 7 (7.40E − 07–1.70E + 21)

0.28

11.57

1.06E + 5 (7.54–1.49E + 09)

0.02

  1. Beta values (ß), hazard ratios and 95% confidence intervals (HR 95% CI), and p-values (P) are reported. Significant associations with TMB, age at diagnosis, IFNγRes, MacReg, Lymphocyte-infiltration signature score, and number of CNV segments are in italic