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Table 2 The results of univariate Cox PH ratio analysis testing the association of 53 immunogenomic covariates with OS in discovery, validation 1, and pooled cohorts

From: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Variable Discovery (N = 139) Validation 1 (N = 70) Pooled (Discovery + validation 1) (N = 209)
ß HR (95% CI) P ß HR (95% CI) P ß HR (95% CI) P
TMB (low) 1.26 3.52 (2.00–6.20) 1.30E–05 1.05 2.86 (1.23–6.62) 0.01 1.21 3.36 (2.10–5.36) 4.01E–07
IFNγRes 0.46 0.63 (0.48–0.84) 1.43E–03 – 0.76 0.47 (0.27–0.82) 8.00E–03  − 0.50 0.60 (0.48–0.77) 4.99E–05
MacReg 0.48 0.62 (0.43–0.88) 8.18E–03 – 0.59 0.56 (0.35–0.89) 0.02  − 0.50 0.61 (0.46–0.80) 3.87E–04
Tumor infiltration (regional) fraction 0.05 0.95 (0.91–0.99) 0.02 – 0.04 0.96 (0.90–1.02) 0.19  − 0.05 0.96 (0.92–0.99) 8.00E–03
Lymphocyte infiltration signature score 0.22 0.80 (0.67–0.97) 2.29E–02 – 0.25 0.78 (0.62–0.99) 0.04  − 0.22 0.80 (0.70–0.93) 2.40E–03
Number of CNV segments 0.00 1.00 (1.00–1.00) 0.02 3.00E–03 1.00 (1.00–1.01) 0.07 1.74E–03 1.00 (1.00–1.00) 4.00E–03
Activated mast cells 0.22 1.24 (1.01–1.53) 0.04 17.38 3.55E + 7 (7.40E − 07–1.70E + 21) 0.28 11.57 1.06E + 5 (7.54–1.49E + 09) 0.02
  1. Beta values (ß), hazard ratios and 95% confidence intervals (HR 95% CI), and p-values (P) are reported. Significant associations with TMB, age at diagnosis, IFNγRes, MacReg, Lymphocyte-infiltration signature score, and number of CNV segments are in italic