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Table 1 Top 10 regulated genes (up/down) by diet, hyperglycemia and treatment

From: Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

Gene symbol Gene name q-value log2-fold change NASH vs CTRL
Upregulated genes
 Grid2ip Glutamate receptor, ionotropic, delta-2 interacting protein-1 1.42 × E−04 4.29
 Htra3 Htra serine peptidase-3 6.51 × E−04 3.80
 Wscd2 WSC domain containing 2 6.51 × E−04 3.75
 Kcnip3 Potassium voltage-gated channel interacting protein-3 4.50 × E−04 3.66
 Gpx6 Glutathione peroxidase-6 3.23 × E−04 3.35
 Fabp3 Fatty-acid binding protein 3 5.21 × E−04 3.30
 Cxcl10 CXC motif chemokine ligand 10 2.27 × E−03 2.84
 Anxa2 Annexin A2 3.46 × E−03 2.48
 Tuba8 Tubulin alpha 8 1.86 × E−04 2.46
 Ubd Ubiquitin D 1.06 × E−03 2.42
Downregulated genes
 Lipg Lipase G 9.35 × E−04 − 3.08
 Cd163 Macrophage-associated antigen 1.28 × E−03 − 2.52
 Sqle Squalene epoxidase 2.45 × E−03 − 2.46
 Pcsk9 Proprotein convertase subtilisin/kexin type 9 3.78 × E−04 − 2.39
 Cish Cytokine inducible SH2 containing protein 1.65 × E−03 − 2.17
 Btg2 B-Cell translocation gene 2.85 × E−03 − 2.12
 Trim24 Tripartite motif containing 24 1.06 × E−03 − 1.83
 Aldh1a3 Aldehyde dehydrogenase 1 family member A3 2.28 × E−03 − 1.66
 Fgb Fibrinogen beta chain 1.78 × E−0.3 − 1.59
 Fgg Fibrinogen gamma chain 1.62 × E−0.3 − 1.58
Gene symbol Gene name q-value log2-fold change NASH-STZ vs NASH
Upregulated genes
 Gpnmb Transmembrane glycoprotein NMB 2.00 × E−03 5.43
 Spp1 Secreted phosphoprotein 1 2.14 × E−03 4.31
 Tff3 Trefoil factor 3 1.29 × E−03 4.27
 Clec4d C-Type lectin domain family 4 member D 1.39 × E−03 3.81
 Chrna1 Cholinergic receptor nicotinic alpha 1 subunit 8.25 × E−04 3.73
 Tm4sf19 Transmembrane 4 L six family member 19 1.28 × E−03 3.68
 Soat1 Sterol O acyltransferase-1 1.02 × E−03 3.64
 Acp5 Tartrate-resistant acid phosphatase 5 9.67 × E−04 3.49
 Ctsh Cathepsin H 9.08 × E−04 3.46
 Clec5a C-type lectin domain family 5 member A 9.76 × E−04 3.42
Downregulated genes
 Hcn3 Hyperpolarization activated cyclic nucleotide gated potassium channel 3 3.71 × E−03 − 4.38
 Serpina5 Serpin family A member 5 3.49 × E−03 − 4.19
 Pnpla3 Patatin-like phospholipase domain containing 3 2.71 × E−03 − 4.13
 Gck Glucokinase 2.13 × E−03 − 3.90
 Pklr Pyruvate kinase L/R 3.10 × E−03 − 3.35
 Mogat2 Monoacylglycerol O-Acyltransferase 2 1.28 × E−03 − 3.02
 Gp5 Glycoprotein V platelet 2.27 × E−03 − 2.91
 Cpxm2 Carboxypeptidase X, M14 family member 2 4.33 × E−03 − 2.80
 Aadacl4 Arylacetamide deacetylase-like 4 6.03 × E−03 − 2.80
 Acly ATP citrate lyase 8.95 × E−04 − 2.72
Gene symbol Gene name q-value log2-fold change NASH-STZ-HI vs NASH-STZ
Upregulated genes
 Hcn3 Hyperpolarization activated cyclic nucleotide gated potassium channel 3 4.48 × E−03 4.25
 Serpina5 Serpine family A member 5 3.81 × E−03 4.14
 Pnpla3 Patatin-like phospholipase domain containing 3 4.74 × E−03 3.65
 Gck Glucokinase 4.44 × E−03 3.57
 Pklr Pyruvate kinase L/R 3.65 × E−03 3.25
 Gp5 Glycoprotein V platelet 3.72 × E−03 2.61
 Abhd5 Abhydrolase domain containing-5 1.71 × E−03 2.12
 Mogat2 Monoacylglycerol O-Acyltransferase 2 2.18 × E−03 2.09
 Me1 NADP-dependent malic enzyme 5.97 × E−03 1.89
 Ppp1r3b Protein phosphatase 1 regulatory subunit 3B 3.33 × E−03 1.77
Downregulated genes
 Tff3 Trefoil factor 3 3.75 × E−03 − 3.42
 Spp1 Secreted phosphoprotein 1 3.77 × E−03 − 3.01
 S100g S100 calcium binding protein G 6.28 × E−03 − 2.92
 Gpnmb Transmembrane glycoprotein NMB 2.96 × E−03 − 2.92
 Soat1 Sterol O-Acyltransferase 1 2.28 × E−03 − 2.84
 Clec4d C-type lectin domain family 4 Member D 6.78 × E−03 − 2.59
 Bst1 Bone marrow stromal cell antigen 1 3.41 × E−03 − 2.59
 Slc16a6 Solute carrier family 16 member 6 3.88 × E−03 − 2.58
 Rpb2 RNA polymerase II gene 2.27 × E−03 − 2.56
 Fst Follistatin 2.27 × E−03 − 2.54