Table 1 Top 10 regulated genes (up/down) by diet, hyperglycemia and treatment
Gene symbol | Gene name | q-value | log2-fold change NASH vs CTRL |
|---|---|---|---|
Upregulated genes | |||
 Grid2ip | Glutamate receptor, ionotropic, delta-2 interacting protein-1 | 1.42 × E−04 | 4.29 |
 Htra3 | Htra serine peptidase-3 | 6.51 × E−04 | 3.80 |
 Wscd2 | WSC domain containing 2 | 6.51 × E−04 | 3.75 |
 Kcnip3 | Potassium voltage-gated channel interacting protein-3 | 4.50 × E−04 | 3.66 |
 Gpx6 | Glutathione peroxidase-6 | 3.23 × E−04 | 3.35 |
 Fabp3 | Fatty-acid binding protein 3 | 5.21 × E−04 | 3.30 |
 Cxcl10 | CXC motif chemokine ligand 10 | 2.27 × E−03 | 2.84 |
 Anxa2 | Annexin A2 | 3.46 × E−03 | 2.48 |
 Tuba8 | Tubulin alpha 8 | 1.86 × E−04 | 2.46 |
 Ubd | Ubiquitin D | 1.06 × E−03 | 2.42 |
Downregulated genes | |||
 Lipg | Lipase G | 9.35 × E−04 | − 3.08 |
 Cd163 | Macrophage-associated antigen | 1.28 × E−03 | − 2.52 |
 Sqle | Squalene epoxidase | 2.45 × E−03 | − 2.46 |
 Pcsk9 | Proprotein convertase subtilisin/kexin type 9 | 3.78 × E−04 | − 2.39 |
 Cish | Cytokine inducible SH2 containing protein | 1.65 × E−03 | − 2.17 |
 Btg2 | B-Cell translocation gene | 2.85 × E−03 | − 2.12 |
 Trim24 | Tripartite motif containing 24 | 1.06 × E−03 | − 1.83 |
 Aldh1a3 | Aldehyde dehydrogenase 1 family member A3 | 2.28 × E−03 | − 1.66 |
 Fgb | Fibrinogen beta chain | 1.78 × E−0.3 | − 1.59 |
 Fgg | Fibrinogen gamma chain | 1.62 × E−0.3 | − 1.58 |
Gene symbol | Gene name | q-value | log2-fold change NASH-STZ vs NASH |
|---|---|---|---|
Upregulated genes | |||
 Gpnmb | Transmembrane glycoprotein NMB | 2.00 × E−03 | 5.43 |
 Spp1 | Secreted phosphoprotein 1 | 2.14 × E−03 | 4.31 |
 Tff3 | Trefoil factor 3 | 1.29 × E−03 | 4.27 |
 Clec4d | C-Type lectin domain family 4 member D | 1.39 × E−03 | 3.81 |
 Chrna1 | Cholinergic receptor nicotinic alpha 1 subunit | 8.25 × E−04 | 3.73 |
 Tm4sf19 | Transmembrane 4 L six family member 19 | 1.28 × E−03 | 3.68 |
 Soat1 | Sterol O acyltransferase-1 | 1.02 × E−03 | 3.64 |
 Acp5 | Tartrate-resistant acid phosphatase 5 | 9.67 × E−04 | 3.49 |
 Ctsh | Cathepsin H | 9.08 × E−04 | 3.46 |
 Clec5a | C-type lectin domain family 5 member A | 9.76 × E−04 | 3.42 |
Downregulated genes | |||
 Hcn3 | Hyperpolarization activated cyclic nucleotide gated potassium channel 3 | 3.71 × E−03 | − 4.38 |
 Serpina5 | Serpin family A member 5 | 3.49 × E−03 | − 4.19 |
 Pnpla3 | Patatin-like phospholipase domain containing 3 | 2.71 × E−03 | − 4.13 |
 Gck | Glucokinase | 2.13 × E−03 | − 3.90 |
 Pklr | Pyruvate kinase L/R | 3.10 × E−03 | − 3.35 |
 Mogat2 | Monoacylglycerol O-Acyltransferase 2 | 1.28 × E−03 | − 3.02 |
 Gp5 | Glycoprotein V platelet | 2.27 × E−03 | − 2.91 |
 Cpxm2 | Carboxypeptidase X, M14 family member 2 | 4.33 × E−03 | − 2.80 |
 Aadacl4 | Arylacetamide deacetylase-like 4 | 6.03 × E−03 | − 2.80 |
 Acly | ATP citrate lyase | 8.95 × E−04 | − 2.72 |
Gene symbol | Gene name | q-value | log2-fold change NASH-STZ-HI vs NASH-STZ |
|---|---|---|---|
Upregulated genes | |||
 Hcn3 | Hyperpolarization activated cyclic nucleotide gated potassium channel 3 | 4.48 × E−03 | 4.25 |
 Serpina5 | Serpine family A member 5 | 3.81 × E−03 | 4.14 |
 Pnpla3 | Patatin-like phospholipase domain containing 3 | 4.74 × E−03 | 3.65 |
 Gck | Glucokinase | 4.44 × E−03 | 3.57 |
 Pklr | Pyruvate kinase L/R | 3.65 × E−03 | 3.25 |
 Gp5 | Glycoprotein V platelet | 3.72 × E−03 | 2.61 |
 Abhd5 | Abhydrolase domain containing-5 | 1.71 × E−03 | 2.12 |
 Mogat2 | Monoacylglycerol O-Acyltransferase 2 | 2.18 × E−03 | 2.09 |
 Me1 | NADP-dependent malic enzyme | 5.97 × E−03 | 1.89 |
 Ppp1r3b | Protein phosphatase 1 regulatory subunit 3B | 3.33 × E−03 | 1.77 |
Downregulated genes | |||
 Tff3 | Trefoil factor 3 | 3.75 × E−03 | − 3.42 |
 Spp1 | Secreted phosphoprotein 1 | 3.77 × E−03 | − 3.01 |
 S100g | S100 calcium binding protein G | 6.28 × E−03 | − 2.92 |
 Gpnmb | Transmembrane glycoprotein NMB | 2.96 × E−03 | − 2.92 |
 Soat1 | Sterol O-Acyltransferase 1 | 2.28 × E−03 | − 2.84 |
 Clec4d | C-type lectin domain family 4 Member D | 6.78 × E−03 | − 2.59 |
 Bst1 | Bone marrow stromal cell antigen 1 | 3.41 × E−03 | − 2.59 |
 Slc16a6 | Solute carrier family 16 member 6 | 3.88 × E−03 | − 2.58 |
 Rpb2 | RNA polymerase II gene | 2.27 × E−03 | − 2.56 |
 Fst | Follistatin | 2.27 × E−03 | − 2.54 |