Fig. 3

Liver histopathology in NASH-STZ hamsters resembled NAFLD and insulin treatment improved hepatic steatosis. Top row: Macroscopic appearance of the livers from CTRL-, NASH-, NASH-STZ- and NASH-STZ-HI immediately after euthanization (left to right). a–d Representative H&E stained sections of liver from CTRL-, NASH-, NASH-STZ- and NASH-STZ-HI hamsters (left to right). e–h Representative Oil Red O stained sections of liver from CTRL-, NASH-, NASH-STZ- and NASH-STZ-HI hamsters (left to right). Insert in g: ×20 magnification of lipid accumulation in hepatocyte. Inserts in a-d: x20 magnifications of H&E-stained sections